Differential risk of fracture attributable to type 2 diabetes mellitus according to skeletal site

Bone ◽  
2022 ◽  
Vol 154 ◽  
pp. 116220
Author(s):  
John T. Schousboe ◽  
Suzanne N. Morin ◽  
Gregory A. Kline ◽  
Lisa M. Lix ◽  
William D. Leslie
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Risk Of Fracture ◽  
Skeletal Site ◽  
Differential Risk

scholarly journals Risk of Fracture in Type 2 Diabetes Mellitus Patients: Meta-Analysis of Observational Studies

2015 ◽  
Vol 18 (7) ◽  
pp. A601 ◽  
Author(s):  
C Shah ◽  
R Shah ◽  
G Kinra ◽  
S Singuru ◽  
M Naidu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Observational Studies ◽  
Meta Analysis ◽  
Risk Of Fracture

scholarly journals Sodium-glucose cotransporter 2 inhibitors and fracture risk in patients with type 2 diabetes mellitus: a meta-analysis of randomized controlled trials

2020 ◽  
Vol 11 ◽  
pp. 204062232096159
Author(s):  
Yake Lou ◽  
Ying Yu ◽  
Junchao Duan ◽  
Sining Bi ◽  
Khaing Nyein Chan Swe ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Subgroup Analysis ◽  
Controlled Trials ◽  
Risk Of Fracture ◽  
Randomized Controlled ◽  
Increased Risk

Background: Patients with type 2 diabetes mellitus (T2DM) have an increased risk of fracture compared with those without T2DM. Some oral glucose-lowering agents may increase the incidence of fracture. Whether sodium-glucose co-transporter 2 inhibitors (SGLT2is) are associated with increased risk of fracture remains unclear. Methods: We retrieved articles from PubMed, Embase, Cochrane Library database, and other sources up to 24 October 2019. We included randomized controlled trials (RCTs) that reported fractures and analyzed the fracture incidence of SGLT2i, canagliflozin, dapagliflozin, and empagliflozin. Subgroup analysis was also performed based on baseline characteristics. Results: A total of 78 RCTs with 85,122 patients were included in our analysis. The overall SGLT2i fracture incidence was 2.56% versus 2.77% in the control group [odds ratio (OR), 1.03; 95% confidence interval (CI) (0.95, 1.12); p = 0.49]. Compared with the control treatment, treatment with canagliflozin led to a higher rate of fractures [OR, 1.17; 95% CI (1.00, 1.37); p = 0.05], but no significant difference was observed when compared with dapagliflozin [OR, 1.02; 95% CI (0.90, 1.15); p = 0.79] or empagliflozin [OR, 0.89; 95% CI (0.73, 1.10); p = 0.30]. Subgroup analysis showed that, in a follow-up of less than 52 weeks, SGLT2i decreased the incidence of fracture by 29% [OR, 0.71; 95% CI (0.55, 0.93); p = 0.01], but this benefit was lost when the follow-up extended to more than 52 weeks [OR, 1.08; 95% CI (0.98, 1.18); p = 0.12]. Conclusion: Canagliflozin seems to increase the risk of fracture, while other SGLT2is do not result in a higher incidence of fracture.

scholarly journals Evaluation of the risk of fracture in type 2 diabetes mellitus patients with incretins: an updated meta-analysis.

2021 ◽  
Author(s):  
Qing-xin KONG ◽  
Qiao Ruan ◽  
Cheng Fan ◽  
Bi-Lin Liu ◽  
Li-Ping Reng ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Meta Analysis ◽  
Risk Of Fracture

Use of dipeptidyl peptidase-4 inhibitors for type 2 diabetes mellitus and risk of fracture

Bone ◽  
2014 ◽  
Vol 68 ◽  
pp. 124-130 ◽  
Author(s):  
Johanna H.M. Driessen ◽  
Hein A.W. van Onzenoort ◽  
Ronald M.A. Henry ◽  
Arief Lalmohamed ◽  
Joop P. van den Bergh ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Dipeptidyl Peptidase ◽  
Risk Of Fracture ◽  
Dipeptidyl Peptidase 4 ◽  
Dipeptidyl Peptidase 4 Inhibitors

scholarly journals Systematic Review of Type 1 and Type 2 Diabetes Mellitus and Risk of Fracture

2007 ◽  
Vol 166 (5) ◽  
pp. 495-505 ◽  
Author(s):  
M. Janghorbani ◽  
R. M. Van Dam ◽  
W. C. Willett ◽  
F. B. Hu
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Risk Of Fracture
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