scholarly journals High-Resolution Mapping of a Repeat Protein Folding Free Energy Landscape

2016 ◽  
Vol 111 (11) ◽  
pp. 2368-2376 ◽  
Author(s):  
Martin J. Fossat ◽  
Thuy P. Dao ◽  
Kelly Jenkins ◽  
Mariano Dellarole ◽  
Yinshan Yang ◽  
...  
Keyword(s):  
Free Energy ◽  
Protein Folding ◽  
High Resolution ◽  
Energy Landscape ◽  
Free Energy Landscape ◽  
Repeat Protein ◽  
High Resolution Mapping ◽  
Resolution Mapping ◽  
Folding Free Energy

scholarly journals Quantifying Nonnative Interactions in the Protein-Folding Free-Energy Landscape

2016 ◽  
Vol 111 (2) ◽  
pp. 287-293 ◽  
Author(s):  
Paulo Ricardo Mouro ◽  
Vinícius de Godoi Contessoto ◽  
Jorge Chahine ◽  
Ronaldo Junio de Oliveira ◽  
Vitor Barbanti Pereira Leite
Keyword(s):  
Free Energy ◽  
Protein Folding ◽  
Energy Landscape ◽  
Free Energy Landscape ◽  
Folding Free Energy

High-resolution free energy landscape analysis of protein folding

2015 ◽  
Vol 43 (2) ◽  
pp. 157-161 ◽  
Author(s):  
Polina V. Banushkina ◽  
Sergei V. Krivov
Keyword(s):  
Free Energy ◽  
Protein Folding ◽  
High Resolution ◽  
Energy Landscape ◽  
Quantitative Description ◽  
Free Energy Landscape ◽  
Transition Path ◽  
Exponential Factor ◽  
Basic Properties ◽  
Folding Dynamics

The free energy landscape can provide a quantitative description of folding dynamics, if determined as a function of an optimally chosen reaction coordinate. The profile together with the optimal coordinate allows one to directly determine such basic properties of folding dynamics as the configurations of the minima and transition states, the heights of the barriers, the value of the pre-exponential factor and its relation to the transition path times. In the present study, we review the framework, in particular, the approach to determine such an optimal coordinate, and its application to the analysis of simulated protein folding dynamics.

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