On the basis of sampling approximation for a function defined on a bounded interval by combining Coiflet-type wavelet expansion and technique of boundary extension, a space-time fully decoupled formulation is proposed to solve multidimensional Schrödinger equations with generalized nonlinearities and damping. By applying a wavelet Galerkin approach for spatial discretization, nonlinear Schrödinger equations are first transformed into a system of ordinary differential equations, in which all matrices are completely independent of time and never need to be recalculated in the time integration. Then, the classical fourth-order explicit Runge–Kutta method is used to solve the resulting semidiscretization system. By studying several widely considered test problems, results demonstrate that when a relatively fine mesh is adopted, the present wavelet algorithm has a much better computational accuracy and efficiency than many existing numerical methods, due to its higher order of convergence in space which can go up to 6.