Comparative Evaluation of Iodine-125 Radioactive Seed Localization and Wire Localization for Resection of Breast Lesions

2017 ◽  
Vol 68 (4) ◽  
pp. 447-455 ◽  
Author(s):  
Vi Thuy Tran ◽  
Julie David ◽  
Erica Patocskai ◽  
Mathieu Zummo-Soucy ◽  
Rami Younan ◽  
...  
Keyword(s):  
Lesion Size ◽  
Breast Lesions ◽  
Wire Localization ◽  
Surgical Specimen ◽  
Equivalent Number ◽  
Seed Localization ◽  
Radioactive Seed Localization ◽  
Radioactive Seed ◽  
Iodine 125 ◽  
Pathology Reports

Purpose Radioactive seed localization (RSL) uses a titanium seed labeled with iodine-125 energy for surgery of nonpalpable breast lesions. RSL facilitates radiology–surgery scheduling and allows for improved oncoplasty compared with wire localization (WL). The purpose of this work was to compare the 2 techniques. Methods We performed a retrospective study of all breast lesions operated with RSL between February 2013 and March 2015 at our university institution, and compared with an equivalent number of surgeries performed with a single WL. Imaging and pathology reports were reviewed for information on guidance mode, accuracy of targeting, nature of excised lesion, size and volume of surgical specimen, status of margins, and reinterventions. Results A total of 254 lesions (247 women) were excised with RSL and compared with 257 lesions (244 women) whose surgery was guided by WL. Both groups were comparable in lesion pathology, guidance mode for RSL or WL positioning, and accuracy of targeting (98% correct). Mean delay between biopsy and surgery was 84 days for RSL versus 103 after WL ( P = .04). No differences were noted after RSL or WL for surgical specimen mean weight, largest diameter, and volume excised. For malignancies, the rate of positive margins was comparable (2.8%-3%), with 5 of 10 women in the RSL group who underwent a second surgery displaying residual malignancy compared with 3 of 9 women in the WL group. Conclusions RSL is safe and accurate, and has comparable surgical endpoints to WL. Because RSL offers flexible scheduling and facilitated oncoplasty, RSL may replace WL for resection of nonpalpable single breast lesions.

Radioactive seed localization of nonpalpable breast lesions is better than wire localization

2004 ◽  
Vol 188 (4) ◽  
pp. 377-380 ◽  
Author(s):  
Richard J. Gray ◽  
Barbara A. Pockaj ◽  
Patricia J. Karstaedt ◽  
Michael C. Roarke
Keyword(s):  
Breast Lesions ◽  
Wire Localization ◽  
Seed Localization ◽  
Radioactive Seed Localization ◽  
Radioactive Seed ◽  
Nonpalpable Breast Lesions ◽  
Better Than

scholarly journals Radioactive Seed Localization for Nonpalpable Breast Lesions in a Community Hospital Setting

2016 ◽  
Vol 5 (1) ◽  
pp. 25
Author(s):  
James A. Wheeler ◽  
Karlyn Harrod ◽  
Fang Liu ◽  
Elizabeth Garber ◽  
Lisa Grove-Narayan ◽  
...  
Keyword(s):  
Hospital Setting ◽  
Positive Margin ◽  
Breast Lesions ◽  
Extensive Literature ◽  
Small Community ◽  
Positive Margin Rate ◽  
Seed Localization ◽  
Radioactive Seed Localization ◽  
Radioactive Seed ◽  
Nonpalpable Breast Lesions

Purpose: To compare the positive margin rates for women with nonpalpable breast tumors whom had wire localization compared to radioactive seed localization in a small community hospital.Introduction: Wire localized (WL) breast biopsies have been performed on patients with nonpalpable breast lesions for many years. Radioactive seed localization (RSL) offers advantages of patient comfort and scheduling convenience.There is an extensive literature from large centers regarding the RSL technique. Little is known whether physicians performing these procedures in smaller community hospitals can achieve comparable negative margin rates as those performed with wire localization.Methods: The thirty-six patients who underwent wire localized breast conserving surgery between September 18, 2013 and December 10, 2014, were compared to the 48 radioactive seed localization patients resected between February 12, 2014 and December 18, 2014. The primary objective was to determine if the introduction of the radioactive seed localization technique significantly changed the positive margin rate.Results: Two of 36 wire localized breast biopsied patients had positive margins, compared to 5 of 48 radioactive seed localization patients, a difference which is not statistically different. The specimen weight was larger for the patients treated with the RSL technique. There was a trend toward a higher positive margin rate with older patients.Conclusion: The positive margin rate was similar between the wire localized and radioactive seed localized patients, and comparable to those in the published literature.

scholarly journals A Single-Institute Experience With Radioactive Seed Localization of Breast Lesions—A Retrospective Study

2020 ◽  
Vol 71 (1) ◽  
pp. 58-62
Author(s):  
Klaudia Jumaa ◽  
Badria Al Johani ◽  
Muriel Brackstone ◽  
Anat Kornecki
Keyword(s):  
Radiology Department ◽  
Resection Margins ◽  
Breast Lesions ◽  
Seed Migration ◽  
Seed Loss ◽  
Seed Localization ◽  
Radioactive Seed Localization ◽  
Malignant Lesions ◽  
Radioactive Seed ◽  
Mean Time

Objectives: To assess the benefits associated with radioactive seed localization (RSL) in comparison to conventional wire localization (WL) for nonpalpable breast lesions. Methods: Radioactive seed localization was initiated at our institution in July 2013. Retrospective review of all WL performed between June 2012 and July 2013 (2013) and all RSL performed during June 2015 and July 2016 (2016). Patients who received neoadjuvant therapy or did not undergo their planned surgeries and WL performed in 2016 were excluded. The following data were collected: final pathology, resection margins for malignant lesions, time to surgery, seed migration, and number of localized lumpectomies performed by each surgeon. Results: A total of 292 WL procedures (288 women) in 2013 and 194 RSL procedures (186 women) in 2016 were eligible for the study. All WLs were inserted the day of surgery. Mean time from RSL insertion to surgery was 4.0 ± 2.8 days (range: 1-17 days). There was no difference in specimen size for malignant lesions (6.8 ± 2.8 cm for WL and 6.9 ± 2.9 cm for RSL; P = .5). Specimen radiographs were obtained in 233 (80%) of 292 WL compared to 194 (100%) of 194 RSL ( P < .001). For malignant lesions, positive margins were present in 34 (17.2%) of 198 with WL compared to 15 (10.3%) of 146 with RSL ( P < .001). Close margins (≤1 mm) were present in 31 (15.6%) of 198 with WL compared to 1 (0.6%) of 146 with RSL ( P < .001). The seed fell out of the specimen during surgery in 6 (3.1%) of 194. No seed loss was recorded. The surgeons (n = 4) who transitioned to RSL increased the number of surgeries per month from a mean of 4.4 ± 2.6 in 2013 to 6.9 ± 3.5 in 2016, equivalent to a 41% increase ( P = .003). Conclusions: The use of RSL, as compared to conventional WL, resulted in a reduction in the number of pathologically involved surgical margins and was associated with an increased number of surgeries. Furthermore, RSL can be performed up to 14 days prior to surgery, which may improve scheduling flexibility in the radiology department.

Localizing High-Risk Lesions for Excisional Breast Biopsy: A Comparison Between Radioactive Seed Localization and Wire Localization

2014 ◽  
Vol 21 (10) ◽  
pp. 3268-3272 ◽  
Author(s):  
Emilia J. Diego ◽  
Atilla Soran ◽  
Kandace P. McGuire ◽  
Corinne Costellic ◽  
Ronald R. Johnson ◽  
...  
Keyword(s):  
High Risk ◽  
Breast Biopsy ◽  
Wire Localization ◽  
Seed Localization ◽  
Radioactive Seed Localization ◽  
Radioactive Seed

scholarly journals Preoperative Localization of Breast MRI Lesions: MRI-guided Marker Placement With Radioactive Seed Localization as an Alternative to MRI-guided Wire Localization

2020 ◽  
Vol 2 (3) ◽  
pp. 250-258
Author(s):  
Nicole Saphier ◽  
Jessica Kondraciuk ◽  
Elizabeth Morris ◽  
Blanca Bernard-Davila ◽  
Victoria Mango
Keyword(s):  
Clinical Indication ◽  
Secondary Outcome ◽  
Procedure Time ◽  
Wire Localization ◽  
Total Procedure Time ◽  
Seed Localization ◽  
Radioactive Seed Localization ◽  
Radioactive Seed ◽  
Mri Guided ◽  
Total Procedure

Abstract Objective Preoperative MRI-guided wire localization (MWL) presents challenges to both the physician and patient. In this study, we examined the efficiency and outcome of MRI-guided marker placement followed by mammographic-guided radioactive seed localization (MMP/RSL) as an alternative localization method. The primary outcome parameter was pathology upon excision. The secondary outcome parameters were total procedure time and clinical indication for localization. Methods A retrospective review of a large tertiary cancer center’s breast imaging database was performed. Records of 21 patients with MMP/RSL (24 markers) from August 2013 to January 2019 were compared with 34 patients receiving MWL (48 wires) from January 2016 to January 2019. Multiple factors, including age, prelocalization pathology, postsurgical pathology, concordance, re-excision rates, and total procedure time required for each technique, were compared. Univariate and descriptive statistical analyses were performed. Results Mean patient age in years (MMP/RSL = 54.1 ± 13.1, MWL = 55.1 ± 10.8, P = 0.389), time in MR scanner in minutes (MMP/RSL = 31.7 ± 12.0, MWL = 35.8 ± 13.1, P = 0.678), and postsurgical pathology malignancy rates (MMP/RSL = 71.4%, MWL = 65.7%, P = 0.7715) were similar without statistically significant differences. As expected, the mean total procedure time was slightly longer without a statistically significant difference (47.3 ± 19.8 min versus 35.8 ± 13.1 min, P = 0.922) for the MMP/RSL group. All patients in both groups underwent successful localization with 100% radiologic-pathology concordance. Re-excision rates were lower for the MMP/RSL group (9.5%) versus the MWL group (16.7%); however, they were not found to be statistically significant (P = 0.7104). Conclusion MMP/RSL is a feasible alternative to MWL and may alleviate many challenges presented by MWL. Further studies are needed.

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