Chemical and enzymatic synthesis of the alginate sugar nucleotide building block: GDP-d-mannuronic acid

Fully bio-based linear oligoesters were obtained by the unprecedented enzymatic polymerization of 5,5′-bis(hydroxymethyl)furoin with succinic and sebacic acid diethyl esters.

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Chemo-enzymatic synthesis of the C15C23 unit of Leptomycin B

Canadian Journal of Chemistry ◽

10.1139/v02-070 ◽

2002 ◽

Vol 80 (6) ◽

pp. 571-576 ◽

Cited By ~ 3

Author(s):

Michael Scheck ◽

Herbert Waldmann

Keyword(s):

Asymmetric Synthesis ◽

Natural Product ◽

Building Block ◽

Enzymatic Synthesis ◽

Aldol Reaction ◽

Natural Product Synthesis ◽

Leptomycin B ◽

Enzymatic Transformation

The asymmetric synthesis of the C15C23 unit of Leptomycin B (LMB) is described. All four stereocenters of the C15C23 unit were prepared from one building block exhibiting only one stereocenter. This building block was synthesized via either an enzymatic transformation or starting from a chiral reagent.Key words: Leptomycin, natural product synthesis, enzymatic transformation, Aldol reaction, Pseudomonas fluorescence lipase (PFL).

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Chemical and enzymatic synthesis of the alginate sugar nucleotide building block: GDP-d-mannuronic acid

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Chemo-enzymatic synthesis of the C15C23 unit of Leptomycin B

Chemo-enzymatic synthesis of the C15C23 unit of Leptomycin B