Measurement of multixenobiotic resistance activity in enchytraeids as a tool in soil ecotoxicology

Chemosphere ◽  
2021 ◽  
pp. 130549
Author(s):  
Marija Kovačević ◽  
Davorka K. Hackenberger ◽  
Željka Lončarić ◽  
Branimir K. Hackenberger
2011 ◽  
Vol 30 (7) ◽  
pp. 1497-1505 ◽  
Author(s):  
Xavier Domene ◽  
Sónia Chelinho ◽  
Paolo Campana ◽  
Tiago Natal-da-Luz ◽  
Josep M. Alcañiz ◽  
...  

2014 ◽  
Vol 103 ◽  
pp. 68-73 ◽  
Author(s):  
Tatiana da Silva Souza ◽  
Cintya Aparecida Christofoletti ◽  
Vlamir Bozzatto ◽  
Carmem Silvia Fontanetti
Keyword(s):  

2001 ◽  
Vol 204 (2) ◽  
pp. 217-227
Author(s):  
J.A. Albertus ◽  
R.O. Laine

Many aquatic organisms are resistant to environmental pollutants, probably because their inherent multi-drug-resistant protein extrusion pump (pgp) can be co-opted to handle man-made pollutants. This mechanism of multixenobiotic resistance is similar to the mechanism of multidrug resistance exhibited in chemotherapy-resistant human tumor cells. In the present study, a variety of techniques were used to characterize this toxin defense system in killifish (Fundulus heteroclitus) hepatocytes. The cellular localization and activity of the putative drug efflux system were evaluated. In addition, in vitro and in vivo studies were used to examine the range of expression of this putative drug transporter in the presence of environmental and chemotherapeutic toxins. The broad range of pgp expression generally observed in transformed mammalian cells was found in normal cells of our teleost model. Our findings suggest that the expression of the pgp gene in the killifish could be an excellent indicator of toxin levels or stressors in the environment.


2016 ◽  
Vol 23 (11) ◽  
pp. 11363-11378 ◽  
Author(s):  
Cintia Carla Niva ◽  
Julia Carina Niemeyer ◽  
Flávio Manoel Rodrigues Da Silva Júnior ◽  
Maria Edna Tenório Nunes ◽  
Danilo Lourenço De Sousa ◽  
...  
Keyword(s):  

1995 ◽  
Vol 39 (1-4) ◽  
pp. 261-265 ◽  
Author(s):  
Branko Kurelec ◽  
Branka Pivcˇević ◽  
Werner E.G. Müller

1998 ◽  
Vol 6 (4) ◽  
pp. 229-238 ◽  
Author(s):  
Werner E.G Müller ◽  
Siegurd Riemer ◽  
Branko Kurelec ◽  
Nenad Smodlaka ◽  
Stasa Puskaric ◽  
...  

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