Theoretical elastic tensile behavior of muscle fiber bundles in traumatic loading events

2019 ◽  
Vol 69 ◽  
pp. 184-190 ◽  
Author(s):  
Atsutaka Tamura ◽  
Jun-ichi Hongu ◽  
Takeo Matsumoto
Keyword(s):  
Muscle Fiber ◽  
Tensile Behavior ◽  
Fiber Bundles

Sarcomere strain and heterogeneity correlate with injury to frog skeletal muscle fiber bundles

2004 ◽  
Vol 97 (5) ◽  
pp. 1803-1813 ◽  
Author(s):  
Tina J. Patel ◽  
Ronnie Das ◽  
Jan Fridén ◽  
Gordon J. Lutz ◽  
Richard L. Lieber
Keyword(s):  
Line Width ◽  
Muscle Fiber ◽  
Muscle Activation ◽  
Sarcomere Length ◽  
Eccentric Contraction ◽  
Fiber Bundles ◽  
Lower Yield ◽  
Bathing Medium ◽  
Average Maximum ◽  
Tetanic Tension

Sarcomere length and first-order diffraction line width were measured by laser diffraction during elongation of activated frog tibialis anterior muscle fiber bundles (i.e., eccentric contraction) at nominal fiber strains of 10, 25, or 35% ( n = 18) for 10 successive contractions. Tetanic tension, measured just before each eccentric contraction, differed significantly among strain groups and changed dramatically during the 10-contraction treatment ( P < 0.01). Average maximum tetanic tension for the three groups measured before any treatment was 203.7 ± 6.8 kN/m2, but after the 10-eccentric contraction sequence decreased to 180.3 ± 3.8, 125.1 ± 7.8, and 78.3 ± 5.1 kN/m2 for the 10, 25, and 35% strain groups, respectively ( P < 0.0001). Addition of 10 mM caffeine to the bathing medium decreased the loss of tetanic tension in the 10% strain group but had only a minimal effect on either the 25 or 35% strain groups. Diffraction pattern line width, a measure of sarcomere length heterogeneity, increased significantly with muscle activation and then continued to increase with successive stretches of the activated muscle. Line width increase after each stretch was significantly correlated with the lower yield tension of the successive contractile record. These data demonstrate a direct association and, perhaps, a causal relationship between sarcomere strain and fiber bundle injury. They also demonstrate that muscle injury is accompanied by a progressive increase in sarcomere length heterogeneity, yielding lower yield tension as injury progresses.

scholarly journals The MyoRobot technology discloses a premature biomechanical decay of skeletal muscle fiber bundles derived from R349P desminopathy mice

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Michael Haug ◽  
Charlotte Meyer ◽  
Barbara Reischl ◽  
Gerhard Prölß ◽  
Kristina Vetter ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Fiber ◽  
Skeletal Muscle Fiber ◽  
Fiber Bundles

THE PREPARATION AND IN VITRO VIABILITY OF ISOLATED EXTERNAL INTERCOSTAL MUSCLE FIBER BUNDLES FROM SHEEP

1984 ◽  
Vol 64 (3) ◽  
pp. 785-789 ◽  
Author(s):  
M. S. WIJAYASINGHE ◽  
L. P. MILLIGAN ◽  
J. R. THOMPSON
Keyword(s):  
Muscle Fiber ◽  
Muscle Metabolism ◽  
Creatine Phosphate ◽  
Fiber Bundles ◽  
Large Animal ◽  
Intercostal Muscle ◽  
Animal Muscle ◽  
Intact Muscle

The preparation of isolated intact muscle fiber bundles from the external intercostal muscle of sheep is described. The fiber bundles maintained both ATP and creatine phosphate at levels similar to those in situ, over a 4-h incubation, and appear to be a suitable preparation for in vitro studies of large animal muscle metabolism. Key words: External intercostal muscle, isolated preparation, metabolic viability, sheep

Clenbuterol and formoterol decrease force production in isolated intact mouse skeletal muscle fiber bundles through a β2-adrenoceptor-independent mechanism

2010 ◽  
Vol 109 (6) ◽  
pp. 1716-1727 ◽  
Author(s):  
Cecilia McCormick ◽  
Leo Alexandre ◽  
Juliette Thompson ◽  
Gabriel Mutungi
Keyword(s):  
Skeletal Muscle ◽  
Muscle Fiber ◽  
Force Production ◽  
Fiber Bundles ◽  
Fiber Types ◽  
Intact Mouse ◽  
Short Acting ◽  
Adrenoceptor Agonists ◽  
Slow Twitch ◽  
Long Acting

Although the acute actions of short-acting β2-adrenoceptor agonists on force production in isolated mammalian skeletal muscle fibers have been the subject of a number of previous studies, those of long-acting β2-adrenoceptor agonists have never been investigated. Also, little is known about the cellular signal transduction events mediating their actions. Therefore, the primary aim of this study was to investigate the acute effects of treatment of mouse fast- and slow-twitch muscle fiber bundles with clenbuterol, formoterol, and salbutamol. Both clenbuterol and salbutamol increased the levels of cAMP in both fiber types, and this effect was reversed by ICI-118551. On the other hand, clenbuterol and formoterol decreased force production in both fiber types. They also increased the phosphorylation of phospholamban and β2-adrenoceptors in slow-twitch fiber bundles, and their effects were insensitive to propranolol, ICI-118551, and 14–22 amide. In contrast, salbutamol increased force production in both fiber types. It also increased the phosphorylation of β2-adrenoceptors in slow-twitch fibers only, but it had no effect on the phosphorylation of phospholamban in either fiber type. These effects were reversed by propranolol and ICI-118551 but not by 14–22 amide. Instead, 14–22 amide further potentiated the effects of salbutamol on force. In summary, long- and short-acting β2-adrenoceptor agonists have opposite effects on force production in isolated intact mouse skeletal muscle fiber bundles. From these results, we suggest that the acute actions of short-acting β2-adrenoceptor agonists on force production in mammalian skeletal muscles are mediated through the β2-adrenoceptor, whereas those of long-acting β2-adrenoceptor agonists are not.

Estimating Blend Ratios from the Tensile Behavior of Wool/Polyester Fiber Bundles

2004 ◽  
Vol 74 (3) ◽  
pp. 198-204 ◽  
Author(s):  
WEIDONG YU ◽  
Haojing Yan ◽  
Ron Postle
Keyword(s):  
Tensile Behavior ◽  
Polyester Fiber ◽  
Fiber Bundles ◽  
Blend Ratios
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