Computational modeling of lumbar disc degeneration before and after spinal fusion

2021 ◽  
pp. 105490
Author(s):  
M.I. Godinho ◽  
V. Carvalho ◽  
M.T. Matos ◽  
P.R. Fernandes ◽  
A.P.G. Castro
2015 ◽  
Vol 3 (5) ◽  
pp. 462-468 ◽  
Author(s):  
Ayato Nohara ◽  
Noriaki Kawakami ◽  
Kenji Seki ◽  
Taichi Tsuji ◽  
Tetsuya Ohara ◽  
...  

Author(s):  
Ziva Majcen ◽  
Tanja Rauter Pungartnik ◽  
Nejc Sarabon

Lower-back related injuries in an athletic population are common and may have severe implications for the athletes sporting career. The focus of this work was to review epidemiology, intervention strategies, and recommendations for return to practice and competition for athletes with lumbar disc degeneration and herniated disc. Conservative treatments for discogenic degeneration and lumbar spine herniation are generally sufficient for athletic populations to restore functional movement. Athletes that fail to respond to conservative measures may consider lumbar discectomy, with high levels of return to pre-competition levels observed following effective surgery. Surgical procedures such as spinal fusion and disc replacement require careful consideration, and should only be recommended if the athlete fails to respond to vigorous conservative treatments. Spinal disc implants have durability and mechanical loading concerns, whereas spinal fusion may ultimately prevent participation in contact sports. Specific guidelines for return to practice and competition remain poorly defined, thus future investigations should address this gap in knowledge. Return to sports should be carefully recommended after the athlete demonstrates sufficient improvements in neuro-physiological, biomechanical, and psychological domains. The correct rehabilitative exercise programme is vital to the rehabilitation of athletes following injury, and should consider frequent monitoring of pain, range of motion and muscle function.


1990 ◽  
Vol 31 (6) ◽  
pp. 551-554
Author(s):  
O. Tervonen ◽  
S. Lahde ◽  
J. Rydberg

Author(s):  
Saeeda Baig

During the recent past focus has shifted from identifying intervertebral disc degeneration as being caused by physical exposure and strain to being linked with a variety of genetic variations. The objective of this review is to provide an up to date review of the existing research data regarding the relation of intervertebral disc degeneration to structural protein genes and their polymorphisms and thus help clearly establish further avenues where research into causation and treatment is needed. A comprehensive search using the keywords “Collagen”, “COL”, “Aggrecan”, “AGC”, “IVDD”, “intervertebral disc degeneration”, and “lumbar disc degeneration” from PubMed and Google Scholar, where literature in the English language was selected spanning from 1991 to 2019. There are many genes involved in the production of structural components of an intervertebral disc. The issues in production of these components involve the over-expression or under-expression of their genes, and single nucleotide polymorphisms and variable number of tandem repeats affecting their structures. These structural genes include primarily the collagen and the aggrecan genes. While genetic and environmental factors all come into play with a disease process like disc degeneration, the bulk of research now shows the significantly larger impact of hereditary over exposure. While further research is needed into some of the lesser studied genes linked to IVDD and also the racial variations in genetic makeup, the focus in the near future should be on establishment of genetic testing to identify individuals at greater risk of disease and deliberation regarding the use of gene therapy to prevent disc degeneration.


2019 ◽  
Vol 60 (12) ◽  
pp. 1636-1642 ◽  
Author(s):  
Bjarke B Hansen ◽  
Urszula M Ciochon ◽  
Charlotte R Trampedach ◽  
Anders F Christensen ◽  
Zoreh Rasti ◽  
...  

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