Immunotherapy related pericardial effusion on chest CT

2022 ◽  
Vol 82 ◽  
pp. 204-209
Author(s):  
Kathleen M. Capaccione ◽  
Sophia Huang ◽  
Zeeshan Toor ◽  
Benjamin May ◽  
Aileen Deng ◽  
...  
Author(s):  
Le Lu ◽  
Jiamin Liu ◽  
Karthik Chellamuthu ◽  
Mohammadhadi Bagheri ◽  
Ronald M. Summers

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
A L Volkova ◽  
V A Bykov ◽  
E V Petrova ◽  
V A Grigoryev ◽  
M Y U Tyurin ◽  
...  

Abstract A 63-year-old man was admitted to the medical intensive care unit because of hypotension and suspected sepsis. Two months before he was admitted to military hospital for cerebrovascular event, considered as transient ischemic attack. Few days after discharge the fever (with a temperature of 39.5°C) occurred and patient was readmitted to the same hospital. Empirical treatment with cefalosporine was inefficient. Only combination carbapenem and vancomycin after E.coli was verified in blood culture stopped the infection. With normal body temperature, normal leukocytes count, mild azotemia, sterile blood and urine cultures and diagnosis of treated urosepsis patient was discharged. Two echocardiogram during hospital stay found no abnormal findings and chest CT scan was also normal. Seven days later, he was seen in our hospital because of fever (with a temperature of 40°C), severe sweating and arterial hypotension. Immediately fluids and norepinephrine infusion was started. Fluoroquinolone was chosen as an antibiotic. There was complete LBBB on ECG that had been registered previously. Leucocyte count at admission was 14 x 109/l and creatinine 300 µmol/l. Transthoracic echo (TTE) reportedly showed evidence of mild aortic and mitral regurgitations, pericardial effusion (1.0 – 1.3 cm with signs of right atrium compression). Aortic root seemed quite normal. On the third day, the number of leukocytes and creatinine increased significantly, reaching 450 µmol/l and 41 x 109/l respectively. Chest CT scan revealed signs of bilateral pneumonia, pericardial and left-sided pleural effusions. Vancomycin and ceftriaxone intravenously were started. Transesophageal echo revealed degenerative changes of aortic valve with mild insufficiency, mild mitral regurgitation. The amount of fluid in the pericardium was approximately unchanged. Patient became normotensive and norepinephrine infusion was discontinued. On the 6th day after admission patient’s temperature became normal, level of creatinine decreased to 230 µkmol/l and leukocytes reached 11.4 x 109/l. On the same day, the patient"s condition worsened. He complained of mild heartburn and progressive weakness, the number of leukocytes and the activity of transaminases increased, his blood pressure dropped to 75/40 mm Hg. This has led to the resumption of norepinephrine infusion. Repeated CT scan revealed inhomogeneous contents in the pericardium. Repeated TTE found increase of pericardial effusion with heterogenous content and signs of cardiac tamponade. Patient was transferred to operating room. After pericardiotomy multiple blood clots and active bleeding from pseudoaneurysm of ascending aorta were found. Despite surgical attempts and massive transfusion, patient died. Autopsy revealed the rupture of pseudoaneurysm of ascending aorta and flat hematoma in pericardium. Abstract P1339 Figure.


2015 ◽  
Vol 57 (5) ◽  
pp. 538-546 ◽  
Author(s):  
Yasutoshi Ohta ◽  
Fuminori Miyoshi ◽  
Toshio Kaminou ◽  
Yasuhiro Kaetsu ◽  
Toshihide Ogawa

2021 ◽  
Vol 94 (1118) ◽  
pp. 20200716
Author(s):  
Mario Silva ◽  
Roberta Eufrasia Ledda ◽  
Mark Schiebler ◽  
Maurizio Balbi ◽  
Sandro Sironi ◽  
...  

Objectives: Ground-glass opacity and consolidation are recognized typical features of Coronavirus disease-19 (COVID-19) pneumonia on Chest CT, yet ancillary findings have not been fully described. We aimed to describe ancillary findings of COVID-19 pneumonia on CT, to define their prevalence, and investigate their association with clinical data. Methods: We retrospectively reviewed our CT chest cases with coupled reverse transcriptase polymerase chain reaction (rt-PCR). Patients with negative rt-PCR or without admission chest CT were excluded. Ancillary findings included: vessel enlargement, subpleural curvilinear lines, dependent subpleural atelectasis, centrilobular solid nodules, pleural and/or pericardial effusions, enlarged mediastinal lymph nodes. Continuous data were expressed as median and 95% confidence interval (95% CI) and tested by Mann–Whitney U test. Results: Ancillary findings were represented by 106/252 (42.1%, 36.1 to 48.2) vessel enlargement, 50/252 (19.8%, 15.4 to 25.2) subpleural curvilinear lines, 26/252 (10.1%, 7.1 to 14.7) dependent subpleural atelectasis, 15/252 (5.9%, 3.6 to 9.6) pleural effusion, 15/252 (5.9%, 3.6 to 9.6) mediastinal lymph nodes enlargement, 13/252 (5.2%, 3 to 8.6) centrilobular solid nodules, and 6/252 (2.4%, 1.1 to 5.1) pericardial effusion. Air space disease was more extensive in patients with vessel enlargement or centrilobular solid nodules (p < 0.001). Vessel enlargement was associated with longer history of fever (p = 0.035) and lower admission oxygen saturation (p = 0.014); dependent subpleural atelectasis with lower oxygen saturation (p < 0.001) and higher respiratory rate (p < 0.001); mediastinal lymph nodes with shorter history of cough (p = 0.046); centrilobular solid nodules with lower prevalence of cough (p = 0.023), lower oxygen saturation (p < 0.001), and higher respiratory rate (p = 0.032), and pericardial effusion with shorter history of cough (p = 0.015). Ancillary findings associated with longer hospital stay were subpleural curvilinear lines (p = 0.02), whereas centrilobular solid nodules were associated with higher rate of intensive care unit admission (p = 0.01). Conclusion: Typical high-resolution CT findings of COVID-19 pneumonia are frequently associated with ancillary findings that variably associate with disease extent, clinical parameters, and disease severity. Advances in knowledge: Ancillary findings might reflect the broad range of heterogeneous mechanisms in severe acute respiratory syndrome from viral pneumonia, and potentially help disease phenotyping.


2019 ◽  
Vol 6 (6) ◽  
pp. 200-202
Author(s):  
José Vitor Rassi Garcia ◽  
Daphine Centola Grassi ◽  
Claudia Cosentino Gallafrio ◽  
Henrique Manoel Lederman

JAMA ◽  
1966 ◽  
Vol 195 (12) ◽  
pp. 1064-1066 ◽  
Author(s):  
W. Dressler
Keyword(s):  

2010 ◽  
Vol 3 (1) ◽  
pp. 5
Author(s):  
BRUCE JANCIN
Keyword(s):  

1977 ◽  
Vol 137 (10) ◽  
pp. 1484b-1485
Author(s):  
G. H. Spodick
Keyword(s):  

Author(s):  
Yale Tung Chen ◽  
Milagros Martí de Gracia ◽  
Maria Luz Parra Gordo ◽  
Silvia Ossaba Velez ◽  
Sergio Agudo-Fernández

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