FC28.3 Changes in nerve excitability properties near the motor nerve terminals in amyotrophic lateral sclerosis

2006 ◽  
Vol 117 ◽  
pp. 1
Author(s):  
S. Misawa ◽  
S. Kuwabara ◽  
M. Nakata ◽  
K. Kanai ◽  
S. Sawai ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Motor Nerve ◽  
Nerve Terminals ◽  
Motor Nerve Terminals ◽  
Nerve Excitability ◽  
Lateral Sclerosis

scholarly journals Autoimmunity in Amyotrophic Lateral Sclerosis: Past and Present

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Mario Rafael Pagani ◽  
Laura Elisabeth Gonzalez ◽  
Osvaldo Daniel Uchitel
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Immune Responses ◽  
Motor Neurons ◽  
Calcium Homeostasis ◽  
Motor Nerve ◽  
Nerve Terminals ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Molecular Features ◽  
Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting particularly motor neurons for which no cure or effective treatment is available. Although the cause of ALS remains unknown, accumulative evidence suggests an autoimmune mechanism of pathogenesis. In this paper, we will summarize the current research related to autoimmunity in the sporadic form of ALS and discuss the potential underlying pathogenic mechanisms and perspectives. Presented data supports the view that humoral immune responses against motor nerve terminals can initiate a series of physiological changes leading to alteration of calcium homeostasis. In turn, loss of calcium homeostasis may induce neuronal death through apoptotic signaling pathways. Additional approaches identifying specific molecular features of this hypothesis are required, which will hopefully allow us to develop techniques of early diagnosis and effective therapies.

Ultrastructural evidence for altered calcium in motor nerve terminals in amyotrophc lateral sclerosis

1996 ◽  
Vol 39 (2) ◽  
pp. 203-216 ◽  
Author(s):  
László Siklós ◽  
József Engelhardt ◽  
Yadollah Harati ◽  
R. Glenn Smith ◽  
Ferenc Joó ◽  
...  
Keyword(s):  
Motor Nerve ◽  
Nerve Terminals ◽  
Motor Nerve Terminals ◽  
Ultrastructural Evidence ◽  
Lateral Sclerosis
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