The risk of misclassification during diagnosis of malnutrition in retroperitoneal sarcoma patients

A middle-aged woman with end-stage renal disease (ESRD) due to obstructive nephropathy presented to the hospital for an episode of unresponsiveness and hypoglycaemia. Initially, she was diagnosed with hypoglycaemia associated with ESRD and was discharged. However, she returned to the hospital after experiencing tonic–clonic seizures and recurrent hypoglycaemia. Her hypoglycaemia workup revealed an elevated insulin-like growth factor 2 (IGF2) to IGF1 ratio consistent with paraneoplastic IGF2 secretion. Subsequently, a CT abdomen revealed a retroperitoneal mass, found to be a retroperitoneal sarcoma. Her hypoglycaemia was treated with glucocorticoids and growth hormone. Surgical debulking of her tumour was attempted, but she expired due to postoperative haemorrhagic shock. Doege-Potter syndrome is a rare cause of hypoglycaemia which should be suspected in any new-onset, worsening, inexplicable or refractory hypoglycaemia, particularly in non-diabetic ESRD. Here we present a report of retroperitoneal sarcoma presenting with hypoglycaemia in a patient with ESRD without diabetes.

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Retroperitoneal sarcoma

Cancer ◽

10.1002/cncr.21761 ◽

2006 ◽

Vol 106 (7) ◽

pp. 1610-1616 ◽

Cited By ~ 123

Author(s):

Geoffrey A. Porter ◽

Nancy N. Baxter ◽

Peter W. T. Pisters

Keyword(s):

Retroperitoneal Sarcoma

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Systemic therapy in retroperitoneal sarcoma management

Journal of Surgical Oncology ◽

10.1002/jso.24933 ◽

2017 ◽

Vol 117 (1) ◽

pp. 87-92 ◽

Cited By ~ 4

Author(s):

Anastasia Constantinidou ◽

Robin L. Jones

Keyword(s):

Systemic Therapy ◽

Retroperitoneal Sarcoma

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Retroperitoneal Sarcoma

Surgical Oncology Clinics of North America ◽

10.1016/j.soc.2016.05.003 ◽

2016 ◽

Vol 25 (4) ◽

pp. 697-711 ◽

Cited By ~ 8

Author(s):

Rebecca A. Gladdy ◽

Abha Gupta ◽

Charles N. Catton

Keyword(s):

Retroperitoneal Sarcoma

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A multi‐institutional validation study of prognostic nomograms for retroperitoneal sarcoma

Journal of Surgical Oncology ◽

10.1002/jso.26586 ◽

2021 ◽

Author(s):

Malcolm H. Squires ◽

Cecilia G. Ethun ◽

Erin E. Donahue ◽

Jennifer H. Benbow ◽

Colin J. Anderson ◽

...

Keyword(s):

Validation Study ◽

Retroperitoneal Sarcoma

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Intraoperative Electron Radiation Therapy in Retroperitoneal Sarcoma

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2017.10.034 ◽

2018 ◽

Vol 100 (2) ◽

pp. 516-527 ◽

Cited By ~ 9

Author(s):

Falk Roeder ◽

Ingo Alldinger ◽

Matthias Uhl ◽

Ladan Saleh-Ebrahimi ◽

Simon Schimmack ◽

...

Keyword(s):

Radiation Therapy ◽

Retroperitoneal Sarcoma ◽

Electron Radiation

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Management of Recurrent Retroperitoneal Sarcoma

10.2310/7800.16104 ◽

2017 ◽

Author(s):

Armen Parsyan ◽

Abha Gupta ◽

Charles Catton ◽

Rebecca Gladdy

Keyword(s):

Local Recurrence ◽

Surgical Resection ◽

Multivisceral Resection ◽

Distant Recurrence ◽

Retroperitoneal Sarcoma ◽

Key Words Chemotherapy ◽

Pattern Of Failure ◽

Mesenchymal Tumors ◽

Retroperitoneal Sarcomas ◽

High Level

Retroperitoneal sarcomas (RPSs) are a heterogeneous group of mesenchymal tumors. The mainstay of treatment of RPS is curative surgical resection, which often involves a multivisceral resection. The predominant pattern of failure in RPS is local recurrence, which poses significant management challenges and limits survival. There is a paucity of high-level evidence to guide the management of primary and recurrent RPS, mainly due to the rarity of the disease. This review highlights the challenges and decision making in the diagnosis and management of recurrent RPS. This review contains 6 figures, 5 tables and 50 references Key words: chemotherapy, distant recurrence, leiomyosarcoma, liposarcoma, local recurrence, radiation therapy, retroperitoneal sarcoma, surgical resection

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