Editorial overview: Relevance of experimental toxicology in human safety evaluation

ChemInform Abstract: The Role of Experimental Toxicology in Safety Evaluation: Challenges Facing the Pharmaceutical Industry

ChemInform ◽

10.1002/chin.199037361 ◽

1990 ◽

Vol 21 (37) ◽

Author(s):

J. C. KAPEGHIAN ◽

V. M. TRAINA

Keyword(s):

Pharmaceutical Industry ◽

Safety Evaluation ◽

Experimental Toxicology

Genetic Toxicity Assessment: Employing the Best Science for Human Safety Evaluation Part VI: When Salt and Sugar and Vegetables Are Positive, How Can Genotoxicity Data Serve to Inform Risk Assessment?

10.1093/toxsci/kfm068 ◽

2007 ◽

Vol 98 (2) ◽

pp. 327-331 ◽

Cited By ~ 18

Author(s):

L. H. Pottenger ◽

J. S. Bus ◽

B. B. Gollapudi

Keyword(s):

Risk Assessment ◽

Safety Evaluation ◽

Toxicity Assessment ◽

Genetic Toxicity ◽

Genetic Toxicity Assessment: Employing the Best Science for Human Safety Evaluation Part VII: Why Not Start with a Single Test: A Transformational Alternative to Genotoxicity Hazard and Risk Assessment

10.1093/toxsci/kfm147 ◽

2007 ◽

Vol 99 (1) ◽

pp. 20-25 ◽

Cited By ~ 18

Author(s):

Warren W. Ku ◽

Jiri Aubrecht ◽

Robert J. Mauthe ◽

Robert H. Schiestl ◽

Albert J. Fornace

Keyword(s):

Risk Assessment ◽

Safety Evaluation ◽

Toxicity Assessment ◽

Single Test ◽

Genetic Toxicity ◽

Human Safety ◽

Hazard And Risk ◽

Hazard And Risk Assessment

Genetic Toxicity Assessment: Employing the Best Science for Human Safety Evaluation

10.1093/toxsci/kfl201 ◽

2006 ◽

Vol 96 (1) ◽

pp. 1-1 ◽

Cited By ~ 1

Author(s):

J. I. Goodman ◽

B. Gollapudi ◽

L. D. Lehman-McKeeman

Keyword(s):

Safety Evaluation ◽

Toxicity Assessment ◽

Genetic Toxicity ◽

Genetic Toxicity Assessment: Employing the Best Science for Human Safety Evaluation Part II: Performances of the In Vitro Micronucleus Test Compared to the Mouse Lymphoma Assay and the In Vitro Chromosome Aberration Assay

10.1093/toxsci/kfl193 ◽

2006 ◽

Vol 96 (2) ◽

pp. 214-217 ◽

Cited By ~ 20

Author(s):

Elisabeth Lorge ◽

Carine Lambert ◽

Véronique Gervais ◽

Nathalie Becourt-Lhote ◽

Jean-Luc Delongeas ◽

...

Keyword(s):

Chromosome Aberration ◽

Micronucleus Test ◽

Safety Evaluation ◽

Toxicity Assessment ◽

Genetic Toxicity ◽

Human Safety ◽

Chromosome Aberration Assay ◽

Mouse Lymphoma Assay ◽

Mouse Lymphoma

Genetic Toxicity Assessment: Employing the Best Science for Human Safety Evaluation Part IV:Recommendation of a Working Group of the Gesellschaft fuer Umwelt-Mutationsforschung (GUM) for a Simple and Straightforward Approach to Genotoxicity Testing

10.1093/toxsci/kfm019 ◽

2007 ◽

Vol 97 (2) ◽

pp. 237-240 ◽

Cited By ~ 51

Author(s):

S. Pfuhler ◽

S. Albertini ◽

R. Fautz ◽

B. Herbold ◽

S. Madle ◽

...

Keyword(s):

Working Group ◽

Safety Evaluation ◽

Toxicity Assessment ◽

Genetic Toxicity ◽

Human Safety ◽

Genotoxicity Testing ◽

Straightforward Approach

The role of experimental toxicology in safety evaluation: Challenges facing the pharmaceutical industry

Medicinal Research Reviews ◽

10.1002/med.2610100205 ◽

1990 ◽

Vol 10 (2) ◽

pp. 271-280 ◽

Cited By ~ 3

Author(s):

John C. Kapeghian ◽

Vincent M. Traina

Keyword(s):

Pharmaceutical Industry ◽

Safety Evaluation ◽

Experimental Toxicology

Genetic Toxicity Assessment: Employing the Best Science for Human Safety Evaluation Part III: The Comet Assay as an Alternative to In Vitro Clastogenicity Tests for Early Drug Candidate Selection

10.1093/toxsci/kfl192 ◽

2007 ◽

Vol 97 (1) ◽

pp. 21-26 ◽

Cited By ~ 58

Author(s):

I. Witte ◽

U. Plappert ◽

H. de Wall ◽

A. Hartmann

Keyword(s):

Comet Assay ◽

Safety Evaluation ◽

Toxicity Assessment ◽

Candidate Selection ◽

Drug Candidate ◽

Genetic Toxicity ◽

Human Safety ◽

Early Drug

Genetic Toxicity Assessment: Employing the Best Science for Human Safety Evaluation Part I: Early Screening for Potential Human Mutagens

10.1093/toxsci/kfl191 ◽

2006 ◽

Vol 96 (1) ◽

pp. 16-20 ◽

Cited By ~ 31

Author(s):

D. Jacobson-Kram ◽

J. F. Contrera

Keyword(s):

Safety Evaluation ◽

Toxicity Assessment ◽

Early Screening ◽

Genetic Toxicity ◽