Non-invasive instantaneous wave-free ratio using coronary CT angiography: diagnostic performance for evaluation of ischaemia-causing coronary stenosis confirmed by invasive fractional flow reserve

2018 ◽  
Vol 73 (11) ◽  
pp. 983.e15-983.e22 ◽  
Author(s):  
Y. Ma ◽  
Y. Hou ◽  
A. Qiao ◽  
Q. Jing ◽  
H. Liu ◽  
...  
Keyword(s):  
Ct Angiography ◽  
Fractional Flow Reserve ◽  
Coronary Stenosis ◽  
Diagnostic Performance ◽  
Coronary Ct Angiography ◽  
Fractional Flow ◽  
Non Invasive ◽  
Coronary Ct ◽  
Flow Reserve

scholarly journals Novel Non-invasive Fractional Flow Reserve from Coronary CT Angiography to Determine Ischemic Coronary Stenosis

2021 ◽  
Vol 15 ◽  
Author(s):  
Lavanya Cherukuri ◽  
Divya Birudaraju ◽  
Matthew J Budoff
Keyword(s):  
Ct Angiography ◽  
Fractional Flow Reserve ◽  
Coronary Ct Angiography ◽  
Invasive Coronary Angiography ◽  
Coronary Calcification ◽  
Fractional Flow ◽  
Non Invasive ◽  
Obstructive Disease ◽  
Coronary Ct ◽  
Flow Reserve

Coronary artery disease (CAD) patients may have an obstructive disease on invasive coronary angiography, but few of these patients have had flow-limiting obstructive disease diagnosed on invasive fractional flow reserve (FFR). FFR is infrequently performed because of its cost- and time-effectiveness. Advancement in non-invasive imaging has enabled FFR to be derived non-invasively using coronary CT angiography (CCTA), without the need for induction of hyperemia or modification of the standard CCTA acquisition protocol. FFR derived from CCTA (FFRCT) has been shown to have excellent correlation with invasive FFR, and remains an effective diagnostic tool in the presence of reduced signal-to-noise ratio, coronary calcification and motion artifact. The utility of FFRCT has also helped to deepen our understanding of hemodynamically significant CAD. Hence, there is now interest in exploring the possible interplay between these mechanistic forces and their effect on the development of coronary plaque and the vulnerability of these plaques.

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