Tau protein aggregation in the frontal and entorhinal cortices as a function of aging

2005 ◽  
Vol 156 (2) ◽  
pp. 127-138 ◽  
Author(s):  
Wencheng Yang ◽  
Lee Cyn Ang ◽  
Michael J. Strong
Keyword(s):  
Protein Aggregation ◽  
Tau Protein

An in vitro study of the role of docosahexaenoic acid in human tau protein aggregation

2016 ◽  
Vol 35 (14) ◽  
pp. 3176-3181
Author(s):  
Elham Sadat Mostafavi ◽  
Mohammad Ali Nasiri Khalili ◽  
Sirus Khodadadi ◽  
Gholam Hossein Riazi
Keyword(s):  
Docosahexaenoic Acid ◽  
Protein Aggregation ◽  
Tau Protein ◽  
In Vitro Study ◽  
Vitro Study

Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model

2003 ◽  
Vol 5 (4) ◽  
pp. 301-308 ◽  
Author(s):  
Mar Pérez ◽  
Félix Hernández ◽  
Filip Lim ◽  
Javier Díaz-Nido ◽  
Jesús Avila
Keyword(s):  
Mouse Model ◽  
Protein Aggregation ◽  
Transgenic Mouse ◽  
Tau Protein ◽  
Lithium Treatment ◽  
Transgenic Mouse Model

O4-11-04: Identification of novel small molecules as tau protein aggregation inhibitors

2012 ◽  
Vol 8 (4S_Part_17) ◽  
pp. P637-P637
Author(s):  
Judy Cam ◽  
Joel Cummings ◽  
Thomas Lake ◽  
Kelsey Hanson ◽  
Luke Esposito ◽  
...  
Keyword(s):  
Protein Aggregation ◽  
Small Molecules ◽  
Tau Protein ◽  
Aggregation Inhibitors

Aβ “Stretching-and-Packing” Cross-Seeding Mechanism Can Trigger Tau Protein Aggregation

2015 ◽  
Vol 6 (16) ◽  
pp. 3276-3282 ◽  
Author(s):  
Ruxi Qi ◽  
Yin Luo ◽  
Guanghong Wei ◽  
Ruth Nussinov ◽  
Buyong Ma
Keyword(s):  
Protein Aggregation ◽  
Tau Protein

scholarly journals In SilicoInsight into Potent of Anthocyanin Regulation of FKBP52 to Prevent Alzheimer’s Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-20 ◽  
Author(s):  
Tzu-Chieh Hung ◽  
Tung-Ti Chang ◽  
Ming-Jen Fan ◽  
Cheng-Chun Lee ◽  
Calvin Yu-Chian Chen
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amino Acids ◽  
Protein Aggregation ◽  
Tau Protein ◽  
Hydrophobic Interactions ◽  
Dynamics Simulation ◽  
Binding Potential ◽  
Ligand Interaction ◽  
Structure Variation

Alzheimer’s disease (AD) is caused by the hyperphosphorylation of Tau protein aggregation. FKBP52 (FK506 binding protein 52) has been found to inhibit Tau protein aggregation. This study found six different kinds of anthocyanins that have high binding potential. After analyzing the docking positions, hydrophobic interactions, and hydrogen bond interactions, several amino acids were identified that play important roles in protein and ligand interaction. The proteins’ variation is described using eigenvectors and the distance between the amino acids during a molecular dynamics simulation (MD). This study investigates the three loops based around Glu85, Tyr113, and Lys121—all of which are important in inducing FKBP52 activation. By performing a molecular dynamic simulation process between unbound proteins and the protein complex with FK506, it was found that ligand targets that docked onto the FK1 domain will decrease the distance between Glu85/Tyr113 and Glu85/Lys121. The FKBP52 structure variation may induce FKBP52 activation and inhibit Tau protein aggregation. The results indicate that anthocyanins might change the conformation of FKBP52 during binding. In addition, the purple anthocyanins, such as cyanidin-3-glucoside and malvidin-3-glucoside, might be better than FK506 in regulating FKBP52 and treating Alzheimer’s disease.

scholarly journals Cellular factors modulating the mechanism of tau protein aggregation

2015 ◽  
Vol 72 (10) ◽  
pp. 1863-1879 ◽  
Author(s):  
Sarah N. Fontaine ◽  
Jonathan J. Sabbagh ◽  
Jeremy Baker ◽  
Carlos R. Martinez-Licha ◽  
April Darling ◽  
...  
Keyword(s):  
Protein Aggregation ◽  
Tau Protein ◽  
Cellular Factors

Xanthohumol inhibits tau protein aggregation and protects cells against tau aggregates

2019 ◽  
Vol 10 (12) ◽  
pp. 7865-7874
Author(s):  
Mohan Zhang ◽  
Qiuping Wu ◽  
Xuanbao Yao ◽  
Junyi Zhao ◽  
Weicong Zhong ◽  
...  
Keyword(s):  
Protein Aggregation ◽  
Tau Protein

Xanthohumol is shown to interact with tau protein and inhibit its aggregation.

Nanobiocatalyst facilitated aglycosidic quercetin as a potent inhibitor of tau protein aggregation

2019 ◽  
Vol 138 ◽  
pp. 168-180 ◽  
Author(s):  
Sanjay Kumar ◽  
V. Guru Krishnakumar ◽  
Vinod Morya ◽  
Sharad Gupta ◽  
Bhaskar Datta
Keyword(s):  
Protein Aggregation ◽  
Tau Protein ◽  
Potent Inhibitor
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