Clinical relevance of pharmacokinetic and pharmacodynamic profiles of insulin degludec (100, 200 U/mL) and insulin glargine (100, 300 U/mL) – a review of evidence and clinical interpretation

D.R. Owens; T. S Bailey; C.G. Fanelli; J.-F. Yale; G.B. Bolli

doi:10.1016/j.diabet.2018.11.004

Clinical relevance of pharmacokinetic and pharmacodynamic profiles of insulin degludec (100, 200 U/mL) and insulin glargine (100, 300 U/mL) – a review of evidence and clinical interpretation

Diabetes & Metabolism ◽

10.1016/j.diabet.2018.11.004 ◽

2019 ◽

Vol 45 (4) ◽

pp. 330-340 ◽

Cited By ~ 3

Author(s):

D.R. Owens ◽

T. S Bailey ◽

C.G. Fanelli ◽

J.-F. Yale ◽

G.B. Bolli

Keyword(s):

Insulin Glargine ◽

Clinical Relevance ◽

Insulin Degludec ◽

Clinical Interpretation

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Real-World Clinical Outcomes of Type 2 Diabetes (T2D) Patients Switching From Insulin Glargine 100 U/mL (Gla-100) or Insulin Detemir (IDet) to Insulin Glargine 300 U/mL (Gla-300) or Insulin Degludec (IDeg)—DELIVER D+ Subgroup Analyses

Diabetes ◽

10.2337/db18-1057-p ◽

2018 ◽

Vol 67 (Supplement 1) ◽

pp. 1057-P

Author(s):

SEAN D. SULLIVAN ◽

TIMOTHY S. BAILEY ◽

RONAN ROUSSEL ◽

FANG L. ZHOU ◽

ZSOLT BOSNYAK ◽

...

Keyword(s):

Type 2 Diabetes ◽

Insulin Glargine ◽

Clinical Outcomes ◽

Real World ◽

Insulin Detemir ◽

Insulin Degludec ◽

Subgroup Analyses

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Comparison between insulin degludec/liraglutide treatment and insulin glargine/lixisenatide treatment in type 2 diabetes: a systematic review and meta-analysis

Expert Opinion on Pharmacotherapy ◽

10.1080/14656566.2017.1400011 ◽

2017 ◽

Vol 18 (17) ◽

pp. 1789-1798 ◽

Cited By ~ 14

Author(s):

Xiaoling Cai ◽

Xueying Gao ◽

Wenjia Yang ◽

Linong Ji

Keyword(s):

Systematic Review ◽

Type 2 Diabetes ◽

Insulin Glargine ◽

Meta Analysis ◽

Insulin Degludec

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Acylated-based long-acting insulin analogues: Is “misfolding” the problem? Commentary letter on Hamasaki H and Yanai H. The switching from insulin glargine to insulin degludec reduced HbA1c, daily insulin doses and anti-insulin antibody in anti-insulin antibody-positive subjects with type 1 diabetes

Diabetes & Metabolism ◽

10.1016/j.diabet.2014.10.001 ◽

2014 ◽

Vol 40 (6) ◽

pp. 483-484 ◽

Cited By ~ 1

Author(s):

L. Monnier ◽

C. Colette ◽

D. Owens

Keyword(s):

Type 1 Diabetes ◽

Insulin Glargine ◽

Insulin Analogues ◽

Insulin Degludec ◽

Insulin Antibody ◽

Daily Insulin ◽

Acting Insulin ◽

Long Acting

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Insulin Degludec Results in Consistently Lower Rates of Nocturnal Hypoglycemia Despite Lower FPG Levels Compared to Insulin Glargine in Seven Trials with T1DM or T2DM

Canadian Journal of Diabetes ◽

10.1016/j.jcjd.2012.07.404 ◽

2012 ◽

Vol 36 (5) ◽

pp. S58-S59

Author(s):

David L. Russell-Jones ◽

Stefano Del Prato ◽

Mari-Anne Gall ◽

Nathan Lassota ◽

Michaela Diamant

Keyword(s):

Insulin Glargine ◽

Insulin Degludec ◽

Nocturnal Hypoglycemia

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Clinical Research of Insulin Glargine U300 basal‐bolus therapy and Insulin Degludec/Aspart Co‐Formulation in Type 2 Diabetes Mellitus: A Real World Experience (CRIGDA Study)

International Journal of Clinical Practice ◽

10.1111/ijcp.14377 ◽

2021 ◽

Author(s):

Savas Volkan Kisioglu ◽

Ahmet Suat Demir ◽

Damla Tufekci ◽

Yasemin Emur Gunay ◽

Hulya Coskun ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Clinical Research ◽

Insulin Glargine ◽

Real World ◽

Insulin Degludec ◽

Basal Bolus

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Is insulin degludec a more effective treatment for patients using high doses of insulin glargine but not attaining euglycemia? Some case reports from India

Diabetes Metabolic Syndrome and Obesity Targets and Therapy ◽

10.2147/dmso.s63878 ◽

2014 ◽

pp. 225

Author(s):

Samit Ghosal ◽

Binayak Sinha ◽

Kalyan Gangopadhyay

Keyword(s):

Insulin Glargine ◽

Effective Treatment ◽

Case Reports ◽

Insulin Degludec ◽

High Doses

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A randomized crossover study of the efficacy and safety of switching from insulin glargine to insulin degludec in children with type 1 diabetes

Endocrine Journal ◽

10.1507/endocrj.ej16-0294 ◽

2017 ◽

Vol 64 (2) ◽

pp. 133-140 ◽

Cited By ~ 8

Author(s):

Tatsuhiko Urakami ◽

Yusuke Mine ◽

Masako Aoki ◽

Misako Okuno ◽

Junichi Suzuki

Keyword(s):

Type 1 Diabetes ◽

Insulin Glargine ◽

Crossover Study ◽

Insulin Degludec ◽

Efficacy And Safety ◽

Randomized Crossover Study

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7.3. Lower Within-Subject Variability in Mean Blood Glucose Concentration with Insulin Degludec vs. Insulin Glargine: A Meta-Analysis of Patients with T2D (914-P)

Nederlands Tijdschrift voor Diabetologie ◽

10.1007/s12467-013-0054-2 ◽

2013 ◽

Vol 11 (3) ◽

pp. 99-100

Author(s):

Luigi F. Meneghini ◽

Stewart B. Harris ◽

Marc Evans ◽

Søren Rasmussen ◽

Thue Johansen ◽

...

Keyword(s):

Blood Glucose ◽

Insulin Glargine ◽

Glucose Concentration ◽

Blood Glucose Concentration ◽

Meta Analysis ◽

Insulin Degludec ◽

Subject Variability ◽

Mean Blood Glucose ◽

Within Subject Variability

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Cost-Effectiveness of Insulin Degludec Compared with Insulin Glargine in a Basal-Bolus Regimen in Patients with Type 1 Diabetes Mellitus in the United Kingdom

Value in Health ◽

10.1016/j.jval.2013.08.685 ◽

2013 ◽

Vol 16 (7) ◽

pp. A442

Author(s):

B. Chubb ◽

M. Evans ◽

M. Wolden ◽

T. Christensen ◽

J. Gundgaard

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

United Kingdom ◽

Cost Effectiveness ◽

Insulin Glargine ◽

Type 1 Diabetes Mellitus ◽

Insulin Degludec ◽

The United Kingdom ◽

Basal Bolus

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Methodological concerns with the meta-analysis comparing insulin degludec/liraglutide and insulin glargine/lixisenatide

Expert Opinion on Pharmacotherapy ◽

10.1080/14656566.2018.1444882 ◽

2018 ◽

Vol 19 (4) ◽

pp. 317-318

Author(s):

Sarah Eggert ◽

Esther Zimmermann ◽

Kamilla Begtrup

Keyword(s):

Insulin Glargine ◽

Meta Analysis ◽

Insulin Degludec

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