P169 - Pyrrolizidine alkaloid DNA adduct formation and the interplay between uptake, metabolism, and efflux in rat sandwich cultured hepatocytes

2020 ◽  
Vol 35 (1) ◽  
pp. S74
Author(s):  
Cindy Obringer ◽  
Cathy Lester ◽  
John Troutman ◽  
Mike Karb ◽  
Yan Xu ◽  
...  
Keyword(s):  
Pyrrolizidine Alkaloid ◽  
Adduct Formation ◽  
Dna Adduct ◽  
Cultured Hepatocytes

Human Liver Microsomal Metabolism and DNA Adduct Formation of the Tumorigenic Pyrrolizidine Alkaloid, Riddelliine

2003 ◽  
Vol 16 (1) ◽  
pp. 66-73 ◽  
Author(s):  
Qingsu Xia ◽  
Ming W. Chou ◽  
Fred. F. Kadlubar ◽  
Po-Cheun Chan ◽  
Peter P. Fu
Keyword(s):  
Human Liver ◽  
Pyrrolizidine Alkaloid ◽  
Adduct Formation ◽  
Dna Adduct ◽  
Microsomal Metabolism

Metabolic activation of the tumorigenic pyrrolizidine alkaloid, monocrotaline, leading to DNA adduct formation in vivo

2005 ◽  
Vol 226 (1) ◽  
pp. 27-35 ◽  
Author(s):  
Yu-Ping Wang ◽  
Jian Yan ◽  
Richard D. Beger ◽  
Peter P. Fu ◽  
Ming W. Chou
Keyword(s):  
Pyrrolizidine Alkaloid ◽  
Metabolic Activation ◽  
Adduct Formation ◽  
Dna Adduct

Metabolic Activation of the Tumorigenic Pyrrolizidine Alkaloid, Riddelliine, Leading to DNA Adduct Formation in Vivo

2001 ◽  
Vol 14 (1) ◽  
pp. 101-109 ◽  
Author(s):  
Ya-Chen Yang ◽  
Jian Yan ◽  
Daniel R. Doerge ◽  
Po-Cheun Chan ◽  
Peter P. Fu ◽  
...  
Keyword(s):  
Pyrrolizidine Alkaloid ◽  
Metabolic Activation ◽  
Adduct Formation ◽  
Dna Adduct

Nitroreduction of 4-Nitropyrene Is Primarily Responsible for DNA Adduct Formation in the Mammary Gland of Female CD Rats

1999 ◽  
Vol 12 (2) ◽  
pp. 180-186 ◽  
Author(s):  
Young-Heum Chae ◽  
Ben-Yi Ji ◽  
Jyh-Ming Lin ◽  
Peter P. Fu ◽  
Bongsup P. Cho ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Adduct Formation ◽  
Dna Adduct
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