Drug Metabolism and Pharmacokinetics
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2625
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Published By Elsevier

1880-0920, 1347-4367
Latest Documents Most Cited Documents Contributed Authors Related Sources Related Keywords

Synthetic mRNA for ex vivo therapeutic applications

2022 ◽  
pp. 100447
Author(s):  
Hideyuki Nakanishi ◽  
Keiji Itaka
Keyword(s):  
Ex Vivo ◽  
Therapeutic Applications ◽  
Synthetic Mrna

Gene and oligonucleotide delivery via micro- and nanobubbles by ultrasound exposure

2022 ◽  
pp. 100445
Author(s):  
Yoko Endo-Takahashi ◽  
Yoichi Negishi
Keyword(s):  
Ultrasound Exposure ◽  
Oligonucleotide Delivery

A UPLC-MS/MS method reveals the pharmacokinetics and metabolism characteristics of kaempferol in rats under hypoxia

2021 ◽  
pp. 100440
Author(s):  
Jing Li ◽  
Yi Wu ◽  
Yi Ma ◽  
Lu Bai ◽  
Qiang Li ◽  
...  

Functional characterization of human organic anion transporter 10 (OAT10/SLC22A13) as an orotate transporter

2021 ◽  
pp. 100443
Author(s):  
Yutaro Shinoda ◽  
Takahiro Yamashiro ◽  
Akira Hosooka ◽  
Tomoya Yasujima ◽  
Hiroaki Yuasa
Keyword(s):  
Organic Anion ◽  
Functional Characterization ◽  
Organic Anion Transporter ◽  
Anion Transporter

A series of simple detection systems for genetic variants of flavin-containing monooxygenase 3 (FMO3) with impaired function in Japanese subjects

2021 ◽  
Vol 41 ◽  
pp. 100420
Author(s):  
Makiko Shimizu ◽  
Ami Mizugaki ◽  
Natsumi Koibuchi ◽  
Haruna Sango ◽  
Yumi Uenuma ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Detection Systems ◽  
Impaired Function ◽  
Simple Detection ◽  
Japanese Subjects

Imaging Mass Spectrometry (IMS) for drug discovery and development survey: Results on methods, applications and regulatory compliance

2021 ◽  
pp. 100438
Author(s):  
Eric Solon ◽  
M. Reid Groseclose ◽  
Stacy Ho ◽  
Kouji Tanaka ◽  
Naoyuki Nakada ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Drug Discovery ◽  
Imaging Mass Spectrometry ◽  
Regulatory Compliance ◽  
Drug Discovery And Development ◽  
Survey Results

Oxidative metabolism and pharmacokinetics of the EGFR inhibitor BIBX1382 in chimeric NOG-TKm30 mice transplanted with human hepatocytes

2021 ◽  
Vol 41 ◽  
pp. 100419
Author(s):  
Shotaro Uehara ◽  
Nao Yoneda ◽  
Yuichiro Higuchi ◽  
Hiroshi Yamazaki ◽  
Hiroshi Suemizu
Keyword(s):  
Oxidative Metabolism ◽  
Human Hepatocytes ◽  
Egfr Inhibitor

Synthesis and evaluation of tofacitinib analogs designed to mitigate metabolic activation

2021 ◽  
pp. 100439
Author(s):  
Yasuhiro Tateishi ◽  
Chikako Shibazaki ◽  
Kyoko Takahashi ◽  
Shigeo Nakamura ◽  
Yasuhiro Kazuki ◽  
...  
Keyword(s):  
Metabolic Activation
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