Pyrrolizidine Alkaloid Secondary Pyrrolic Metabolites Construct Multiple Activation Pathways Leading to DNA Adduct Formation and Potential Liver Tumor Initiation

2018 ◽  
Vol 31 (7) ◽  
pp. 619-628 ◽  
Author(s):  
Qingsu Xia ◽  
Xiaobo He ◽  
Liang Ma ◽  
Shoujun Chen ◽  
Peter P. Fu
Keyword(s):  
Liver Tumor ◽  
Pyrrolizidine Alkaloid ◽  
Adduct Formation ◽  
Dna Adduct ◽  
Tumor Initiation ◽  
Activation Pathways

Human Liver Microsomal Metabolism and DNA Adduct Formation of the Tumorigenic Pyrrolizidine Alkaloid, Riddelliine

2003 ◽  
Vol 16 (1) ◽  
pp. 66-73 ◽  
Author(s):  
Qingsu Xia ◽  
Ming W. Chou ◽  
Fred. F. Kadlubar ◽  
Po-Cheun Chan ◽  
Peter P. Fu
Keyword(s):  
Human Liver ◽  
Pyrrolizidine Alkaloid ◽  
Adduct Formation ◽  
Dna Adduct ◽  
Microsomal Metabolism

Metabolic activation of the tumorigenic pyrrolizidine alkaloid, monocrotaline, leading to DNA adduct formation in vivo

2005 ◽  
Vol 226 (1) ◽  
pp. 27-35 ◽  
Author(s):  
Yu-Ping Wang ◽  
Jian Yan ◽  
Richard D. Beger ◽  
Peter P. Fu ◽  
Ming W. Chou
Keyword(s):  
Pyrrolizidine Alkaloid ◽  
Metabolic Activation ◽  
Adduct Formation ◽  
Dna Adduct
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