Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers

2019 ◽  
Vol 182 ◽  
pp. 111655 ◽  
Author(s):  
Elisabetta Teodori ◽  
Marialessandra Contino ◽  
Chiara Riganti ◽  
Gianluca Bartolucci ◽  
Laura Braconi ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Discovery to solve multidrug resistance: Design, synthesis, and biological evaluation of novel agents

2019 ◽  
Vol 352 (10) ◽  
pp. 1900127 ◽  
Author(s):  
Qianqian Qiu ◽  
Wei Shi ◽  
Shiyuan Zhao ◽  
Yan Zhu ◽  
Zhengquan Ding ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Biological Evaluation ◽  
Novel Agents ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Design, synthesis and biological evaluation of novel triazole-core reversal agents against P-glycoprotein-mediated multidrug resistance

RSC Advances ◽  
2016 ◽  
Vol 6 (31) ◽  
pp. 25819-25828 ◽  
Author(s):  
Bo Zhang ◽  
Tianxiao Zhao ◽  
Jie Zhou ◽  
Qianqian Qiu ◽  
Yuxuan Dai ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Click Chemistry ◽  
Biological Evaluation ◽  
Glycoprotein P ◽  
Design Synthesis ◽  
Reversal Agents ◽  
P Glycoprotein ◽  
Synthesis And Biological Evaluation

We designed and synthesized a novel series of P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) inhibitors bearing a triazolphenethyl–tetrahydroisoquinoline scaffold through click chemistry.

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