The impact of naloxegol on anal sphincter function - Using a human experimental model of opioid-induced bowel dysfunction

2018 ◽  
Vol 117 ◽  
pp. 187-192 ◽  
Author(s):  
Debbie Grønlund ◽  
Jakob L. Poulsen ◽  
Klaus Krogh ◽  
Christina Brock ◽  
Donghua Liao ◽  
...  
Keyword(s):  
Experimental Model ◽  
Anal Sphincter ◽  
Bowel Dysfunction ◽  
Sphincter Function ◽  
Anal Sphincter Function ◽  
The Impact

Oxycodone and macrogol 3350 treatment reduces anal sphincter relaxation compared to combined oxycodone and naloxone tablets

2017 ◽  
Vol 16 (1) ◽  
pp. 179-179
Author(s):  
Jakob Lykke Poulsen ◽  
Christina Brock ◽  
Debbie Grønlund ◽  
Klaus Krogh ◽  
Asbjørn Mohr Drewes
Keyword(s):  
Anal Canal ◽  
Anal Sphincter ◽  
Bowel Dysfunction ◽  
Stool Consistency ◽  
Sphincter Function ◽  
Anal Sphincter Function ◽  
Rectoanal Inhibitory Reflex ◽  
Resting Pressure ◽  
Anal Resting Pressure ◽  
Inhibitory Reflex

Abstract Background Opioid analgesics inhibit anal sphincter function and contribute to opioid-induced bowel dysfunction. However, it is unknown if the inhibition can be reduced by opioid antagonism with oral naloxone, and how this compares to osmotic laxative treatment. Aims To compare the effects of oxycodone and macrogol 3350 treatment (OX + PEG) versus combined oral oxycodone and naloxone (OXN) on anal sphincter function and gastrointestinal symptoms. Methods A randomised, double-blind, crossover trial was conducted in 20 healthy, male volunteers. Participants were randomised to five days treatment of OX + PEG or OXN. Anal resting pressure, anal canal distensibility, and rectoanal inhibitory reflex-induced sphincter relaxation were evaluated at baseline and on day 5. The Patient Assessment of Constipation questionnaire (PAC-SYM), stool frequency, and stool consistency were assed daily. Results Sphincter relaxation was reduced after OX + PEG treatment compared to OXN (difference = −17.6% [95% Cl;−25.2, −10.2]; P < 0.001). Anal resting pressure and anal canal distensibility did not differ between the treatments. PAC-SYM abdominal symptom subscale increased during OX + PEG compared to OXN (cumulated score: 3.2±2.3 vs. 0.2±1.8; P =0.002). Number of bowel movements was higher during OX + PEG vs. OXN (5.4±1.5 vs. 4.2±1.2; P = 0.035), but there was no difference in stool consistency (3.5±0.5 vs. 3.2±0.4; P = 0.14). Conclusions Sphincter relaxation was significantly reduced after OX + PEG compared to OXN. Evaluation of the rectoanal inhibitory reflex may serve as an important objective measure in future trials on treatment of opioid-induced bowel dysfunction.

Traditional measures of normal anal sphincter function using high-resolution anorectal manometry (HRAM) in 115 healthy volunteers

2014 ◽  
Vol 26 (5) ◽  
pp. 625-635 ◽  
Author(s):  
E. V. Carrington ◽  
A. Brokjaer ◽  
H. Craven ◽  
N. Zarate ◽  
E. J. Horrocks ◽  
...  
Keyword(s):  
High Resolution ◽  
Healthy Volunteers ◽  
Anal Sphincter ◽  
Anorectal Manometry ◽  
Sphincter Function ◽  
Anal Sphincter Function

Anal sphincter function and rectal reservoir after sphincter saving operations for carcinoma of the rectum

1983 ◽  
Vol 13 (5) ◽  
pp. 420-425 ◽  
Author(s):  
Naomi Iwai ◽  
Kyozo Hashimoto ◽  
Hirofumi Kaneda ◽  
Osamu Kojima ◽  
Bunzo Nishioka ◽  
...  
Keyword(s):  
Anal Sphincter ◽  
Carcinoma Of The Rectum ◽  
Sphincter Function ◽  
Anal Sphincter Function ◽  
Sphincter Saving

Restoration of Anal Sphincter Function by Single-Stage Dynamic Graciloplasty with a Modified (Split Sling) Technique

1998 ◽  
Vol 175 (3) ◽  
pp. 187-193 ◽  
Author(s):  
Harald R. Rosen ◽  
Gabriele Novi ◽  
Gerald Zoech ◽  
Wolfgang Feil ◽  
Christina Urbarz ◽  
...  
Keyword(s):  
Anal Sphincter ◽  
Single Stage ◽  
Dynamic Graciloplasty ◽  
Sphincter Function ◽  
Anal Sphincter Function

Effect of anorectal eversion during restorative proctocolectomy on anal sphincter function

1993 ◽  
Vol 80 (1) ◽  
pp. 121-123 ◽  
Author(s):  
W. G. Lewis ◽  
P. J. Holdsworth ◽  
P. M. Sagar ◽  
J. P. Blandy ◽  
J. H. M. Holmfield ◽  
...  
Keyword(s):  
Anal Sphincter ◽  
Restorative Proctocolectomy ◽  
Sphincter Function ◽  
Anal Sphincter Function
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