scholarly journals SUN-037 NO IMPACT OF NEWLY INITIATED IMMUNOSUPPRESSIVE THERAPY OBSERVED ON LONG-TERM ANTIPROTEINURIC EFFECT OF SPARSENTAN IN FOCAL SEGMENTAL GLOMERULOSCLEROSIS: INTERIM 84-WEEK ANALYSIS OF THE DUET TRIAL

2019 ◽  
Vol 4 (7) ◽  
pp. S168-S169 ◽  
Author(s):  
V. Tesar ◽  
H. Trachtman ◽  
E. Murphy ◽  
B. Ferguson ◽  
R. Komers
Keyword(s):  
Immunosuppressive Therapy ◽  
Focal Segmental Glomerulosclerosis ◽  
Segmental Glomerulosclerosis ◽  
Antiproteinuric Effect

scholarly journals Successful long-term management of recurrent focal segmental glomerulosclerosis after kidney transplantation with costimulation blockade

2020 ◽  
Author(s):  
Thomas Mühlbacher ◽  
Kerstin Amann ◽  
Moritz Mahling ◽  
Silvio Nadalin ◽  
Nils Heyne ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Focal Segmental Glomerulosclerosis ◽  
Costimulation Blockade ◽  
Segmental Glomerulosclerosis ◽  
Remission Maintenance ◽  
Maintenance Immunosuppression ◽  
Therapeutic Concepts ◽  
Allograft Outcome

Abstract Recurrence of primary focal segmental glomerulosclerosis (FSGS) occurs in up to 50% of patients after kidney transplantation and is associated with poor allograft outcome. Novel therapeutic concepts directly target podocyte function via B7-1 with inconsistent response. We present the case of a 19 yr. old patient with recurrent primary FSGS early after living donor kidney transplantation. Plasmapheresis and rituximab did not induce remission. Repetitive abatacept administration was able to achieve partial remission. Maintenance immunosuppression was subsequently switched to a belatacept-based CNI-free immunosuppression, resulting in sustained complete remission with excellent allograft function throughout a follow-up of more than 56 months.

Long-term outcome of focal segmental glomerulosclerosis after Japanese pediatric renal transplantation

2002 ◽  
Vol 17 (3) ◽  
pp. 165-168 ◽  
Author(s):  
M. Fujisawa ◽  
Kazumoto Iijima ◽  
Takeshi Ishimura ◽  
Akihiro Higuchi ◽  
Shuji Isotani ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Focal Segmental Glomerulosclerosis ◽  
Pediatric Renal Transplantation ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Segmental Glomerulosclerosis

Predictors of long-term outcome of children with idiopathic focal segmental glomerulosclerosis

2007 ◽  
Vol 22 (2) ◽  
pp. 215-221 ◽  
Author(s):  
Asiri S. Abeyagunawardena ◽  
Neil J. Sebire ◽  
R. Anthony Risdon ◽  
Michael J. Dillon ◽  
Lesley Rees ◽  
...  
Keyword(s):  
Focal Segmental Glomerulosclerosis ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Segmental Glomerulosclerosis

scholarly journals Recurrent Focal Segmental Glomerulosclerosis in Renal Allograft Recipients: Role of Human Leukocyte Antigen Mismatching and Other Clinical Variables

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Shimi Sharief ◽  
Shefali Mahesh ◽  
Marcela Del Rio ◽  
Vivian Telis ◽  
Robert P. Woroniecki
Keyword(s):  
Focal Segmental Glomerulosclerosis ◽  
Pediatric Population ◽  
Surrogate Marker ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Clinical Variables ◽  
Segmental Glomerulosclerosis ◽  
Hla Compatibility

Recurrence of focal segmental glomerulosclerosis (FSGS) after renal transplantation impacts long-term graft survival and limits access to transplantation. We hypothesized that HLA donor/recipient matching could be used as a surrogate marker of recurrence. In a retrospective study of 42 pediatric and 77 adult subjects with primary FSGS, transplanted from 1990 to 2007 at a single center, we analyzed the degree of donor/recipient HLA compatibility and other clinical variables associated with FSGS recurrence. There were total of 131 allografts for primary FSGS (11 subjects were transplanted twice, and 1 had a third allograft) with 20 cases of FSGS recurrence (17 children) in the primary allograft, and two children who had FSGS recurrence in the second allograft. Fifty-two subjects (40%) were African American, and 66 (50%) Caucasians. Recurrent FSGS and controls were not different for age at transplant, gender, donor source, acute/chronic rejection episodes, and HLA matches. Recurrent FSGS was not associated with HLA mismatches; power equals 83%. Immunosuppressive regimen had no effect on recurrence of FSGS, . Recurrent FSGS is not associated with HLA mismatching, acute cellular or vascular rejection, and occurs primarily in the pediatric population.

Primary focal segmental glomerulosclerosis - Long-term outcome after pediatric renal transplantation

2005 ◽  
Vol 9 (2) ◽  
pp. 226-231 ◽  
Author(s):  
Therese C. Jungraithmayr ◽  
Monika Bulla ◽  
Jürgen Dippell ◽  
Christel Greiner ◽  
Martin Griebel ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Focal Segmental Glomerulosclerosis ◽  
Pediatric Renal Transplantation ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Segmental Glomerulosclerosis
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