AbstractNeurobiology-based interventions for mental diseases and searches for useful biomarkers of treatment response have largely failed. Clinical trials should assess interventions related to environmental and social stressors, with long-term follow-up; social rather than biological endpoints; personalized outcomes; and suitable cluster, adaptive, and n-of-1 designs. Labor, education, financial, and other social/political decisions should be evaluated for their impacts on mental disease.
TU22. SPATIOTEMPORAL MODULARITY OF GWAS GENES (STGWAS) IDENTIFIED DISTINCT EFFECT OF PRENATAL AND POSTNATAL BRAIN EXPRESSION ACROSS 20 BRAIN DISORDERS AND ANTHROPOMETRIC SOCIAL TRAITS
