Effect of Mitomycin C on Anterior Urethral Stricture Recurrence after Internal Urethrotomy

2007 ◽  
Vol 51 (4) ◽  
pp. 1089-1092 ◽  
Author(s):  
Hamid Mazdak ◽  
Iraj Meshki ◽  
Fatemeh Ghassami
Keyword(s):  
Mitomycin C ◽  
Urethral Stricture ◽  
Internal Urethrotomy ◽  
Stricture Recurrence

MP-12.01 Efficacy of Intraurethral Mitomycin C Hydrogel in Prevention from Anterior Urethral Stricture Recurrence After Internal Urethrotomy

Urology ◽  
2011 ◽  
Vol 78 (3) ◽  
pp. S116
Author(s):  
M. Moradi ◽  
B. Karimian ◽  
K. Derakhshandeh ◽  
M. Fashi ◽  
B. Samadzadeh ◽  
...  
Keyword(s):  
Mitomycin C ◽  
Urethral Stricture ◽  
Internal Urethrotomy ◽  
Stricture Recurrence

443: Can Self-Calibration Prevent Urethral Stricture Recurrence Following Direct Visual Internal Urethrotomy?

2005 ◽  
Vol 173 (4S) ◽  
pp. 121-121
Author(s):  
Hari Siva Gurunadha Rao Tunuguntla ◽  
P.V.L.N. Murthy ◽  
K. Sasidharan
Keyword(s):  
Urethral Stricture ◽  
Internal Urethrotomy ◽  
Self Calibration ◽  
Stricture Recurrence

scholarly journals Internal urethrotomy versus plasmakinetic energy for surgical treatment of urethral stricture

2015 ◽  
Vol 87 (2) ◽  
pp. 161 ◽  
Author(s):  
Levent Ozcan ◽  
Emre Can Polat ◽  
Alper Otunctemur ◽  
Efe Onen ◽  
Oğuz Ozden Cebeci ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Urethral Stricture ◽  
Maximum Flow ◽  
Clinical History ◽  
Internal Urethrotomy ◽  
Urethral Strictures ◽  
Cold Knife ◽  
Group 2 ◽  
Stricture Recurrence ◽  
Group 1

Purpose: we aimed to compare the longterm outcome of surgical treatment of urethral stricture with the internal urethrotomy and plasmakinetic energy. Material and Methods: 60 patients, who have been operated due to urethral stricture were enrolled in our clinic. None of the patients had a medical history of urethral stricture. The urethral strictures were diagnosed by clinical history, uroflowmetry, ultrasonography and urethrography. The patients were divided two groups. Group 1 consisted of 30 patients treated with plasmakinetic urethrotomy and group 2 comprised 30 men treated with cold knife urethrotomy. Results: There were no statistically significant differences between two groups in terms of patient age, maximum flow rate (Qmax) and quality of life score (Qol) value. A statistical difference between the two groups was observed when we compared the 3rd-month uroflowmetry results. Group 1 patients had a mean postoperative Qmax value of 16,1 ± 2,3 ml/s, whereas group 2 had a mean postoperative Qmax value of 15,1 ± 2,2 ml/s (p < 0.05). In the cold knife group, 3 of 11 (27,7%) recurrences appeared within the first 3 months, whereas in the plasmakinetic group zero recurrences appeared within the first 3 months in our study. The urethral stricture recurrence rate up to the 12 month period was statistically significant for group 1 (n = 7, 23%) compared with group 2 (n = 11, 37%) (p < 0.05). Conclusion: We believe that plasmakinetic surgery is better method than the cold knife technique for the treatment of urethral stricture.

scholarly journals Efficacy of Optical Internal Urethrotomy and Intralesional Injection of Vatsala-Santosh PGI Tri-Inject (Triamcinolone, Mitomycin C, and Hyaluronidase) in the Treatment of Anterior Urethral Stricture

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Santosh Kumar ◽  
Nitin Garg ◽  
Shrawan Kumar Singh ◽  
Arup Kumar Mandal
Keyword(s):  
Success Rate ◽  
Mitomycin C ◽  
Recurrence Rate ◽  
Urethral Stricture ◽  
Clinical History ◽  
Therapeutic Modality ◽  
Intralesional Injection ◽  
Internal Urethrotomy ◽  
Retrograde Urethrogram ◽  
Optical Internal Urethrotomy

Purpose. To study the efficacy of optical internal urethrotomy with intralesional injection of Vatsala-Santosh PGI tri-inject (triamcinolone, mitomycin C, and hyaluronidase) in the treatment of anterior urethral stricture.Material and Methods. A total of 103 patients with symptomatic anterior urethral stricture were evaluated on the basis of clinical history, physical examination, uroflowmetry, and retrograde urethrogram preoperatively. All patients were treated with optical internal urethrotomy followed by injection of tri-inject at the urethrotomy site. Tri-inject was prepared by diluting the combination of triamcinolone 40 mg, mitomycin C 2 mg, and hyaluronidase 3000 in 5–10 mL of saline according to length of stricture. An indwelling 18 Fr silicone catheter was left in place for a period of 7–21 days. All patients were followed up for 6–18 months postoperatively on the basis of history, uroflowmetry, and, if required, retrograde urethrogram and micturating urethrogram every 3 months.Results. The overall recurrence rate after first OIU is 19.4% (20 out of 103 patients), that is, a success rate of 80.6%. Overall recurrence rate after second procedure was 5.8% (6 out of 103 patients), that is, a success rate of 94.2%.Conclusion. Optical internal urethrotomy with intralesional injection of Vatsala-Santosh PGI tri-inject (triamcinolone, mitomycin C, and hyaluronidase) is a safe and effective minimally invasive therapeutic modality for short segment anterior urethral strictures.

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