Neuroprotection in the rat lateral fluid percussion model of traumatic brain injury by SNX-185, an N-type voltage-gated calcium channel blocker

2004 ◽  
Vol 190 (1) ◽  
pp. 70-78 ◽  
Author(s):  
Lillian L. Lee ◽  
Ethel Galo ◽  
Bruce G. Lyeth ◽  
J. Paul Muizelaar ◽  
Robert F. Berman
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Channel Blocker ◽  
Voltage Gated ◽  
Fluid Percussion ◽  
Voltage Gated Calcium Channel ◽  
Lateral Fluid Percussion

scholarly journals Voltage-Gated Calcium Channel Antagonists and Traumatic Brain Injury

2013 ◽  
Vol 6 (7) ◽  
pp. 788-812 ◽  
Author(s):  
Gene Gurkoff ◽  
Kiarash Shahlaie ◽  
Bruce Lyeth ◽  
Robert Berman
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Calcium Channel ◽  
Calcium Channel Antagonists ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channel

scholarly journals Nilvadipine, a New Calcium Channel Blocker, Reduces Ischemic Brain Injury in Rats

1991 ◽  
Vol 56 (4) ◽  
pp. 547-550
Author(s):  
Shoji Takakura ◽  
Teruo Susumu ◽  
Hisashi Satoh ◽  
Jo Mori ◽  
Akihiko Shiino ◽  
...  
Keyword(s):  
Brain Injury ◽  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Channel Blocker ◽  
Ischemic Brain Injury ◽  
Ischemic Brain

Evaluation of a novel calcium channel blocker, (S)-emopamil, on regional cerebral edema and neurobehavioral function after experimental brain injury

1992 ◽  
Vol 77 (4) ◽  
pp. 607-615 ◽  
Author(s):  
Koichi Okiyama ◽  
Douglas H. Smith ◽  
Mark J. Thomas ◽  
Tracy K. McIntosh
Keyword(s):  
Brain Injury ◽  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Motor Function ◽  
Cerebral Edema ◽  
Channel Blocker ◽  
Memory Function ◽  
Tissue Water ◽  
Content Type ◽  
Neurobehavioral Function

✓ The authors investigated the effects of a novel calcium channel blocker, (S)-emopamil, on cerebral edema and neurobehavioral and memory function following experimental fluid-percussion brain injury in the rat. Two independent experiments were performed to evaluate the effects of this compound on cardiovascular variables and postinjury cerebral edema (increases in tissue water content), and on cognitive deficits and neurological motor function following brain injury. Treatment with (S)-emopamil significantly reduced focal brain edema at 48 hours after brain injury. Profound memory dysfunction induced by brain injury was significantly attenuated following (S)-emopamil treatment. In addition, (S)-emopamil also attenuated the deficits in motor function that were observed over a 2-week period following brain injury. These results suggest that changes in calcium homeostasis may play an important role in the pathogenesis of trauma to the central nervous system and that the calcium channel blocker (S)-emopamil might be a useful compound for the treatment of traumatic brain injury.

The Up-Regulation of Voltage-Gated Sodium Channel NaV1.6 Expression Following Fluid Percussion Traumatic Brain Injury in Rats

Neurosurgery ◽  
2010 ◽  
Vol 66 (6) ◽  
pp. 1134-1139 ◽  
Author(s):  
Qing Mao ◽  
Feng Jia ◽  
Xiao-hua Zhang ◽  
Yong-ming Qiu ◽  
Jian-wei Ge ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Sodium Channel ◽  
Voltage Gated Sodium Channel ◽  
Voltage Gated ◽  
Fluid Percussion
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