scholarly journals A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. I. Inhalation exposure, clinical pathology and histopathology

2018 ◽  
Vol 116 ◽  
pp. 388-413 ◽  
Author(s):  
Blaine W. Phillips ◽  
Walter K. Schlage ◽  
Bjoern Titz ◽  
Ulrike Kogel ◽  
Davide Sciuscio ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Inhalation Exposure ◽  
Clinical Pathology ◽  
Tobacco Product ◽  
Inhalation Study ◽  
Systems Toxicology

scholarly journals Effects of cigarette smoke, cessation and switching to a candidate modified risk tobacco product on the liver in Apoe−/− mice – a systems toxicology analysis

2016 ◽  
Vol 28 (5) ◽  
pp. 226-240 ◽  
Author(s):  
Giuseppe Lo Sasso ◽  
Bjoern Titz ◽  
Catherine Nury ◽  
Stéphanie Boué ◽  
Blaine Phillips ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Tobacco Product ◽  
Systems Toxicology ◽  
Smoke Cessation

Systems Toxicology meta-analysis: Impact of a candidate modified-risk tobacco product aerosol compared with cigarette smoke on organotypic aerodigestive tract cultures

2017 ◽  
Vol 280 ◽  
pp. S262-S263
Author(s):  
Anita R. Iskandar ◽  
Bjoern Titz ◽  
Alain Sewer ◽  
Patrice Leroy ◽  
Thomas Schneider ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Meta Analysis ◽  
Tobacco Product ◽  
Aerodigestive Tract ◽  
Systems Toxicology

scholarly journals Systems toxicology meta-analysis of in vitro assessment studies: biological impact of a candidate modified-risk tobacco product aerosol compared with cigarette smoke on human organotypic cultures of the aerodigestive tract

2017 ◽  
Vol 6 (5) ◽  
pp. 631-653 ◽  
Author(s):  
A. R. Iskandar ◽  
B. Titz ◽  
A. Sewer ◽  
P. Leroy ◽  
T. Schneider ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Meta Analysis ◽  
Tobacco Product ◽  
Aerodigestive Tract ◽  
Organotypic Cultures ◽  
Biological Impact ◽  
Systems Toxicology ◽  
In Vitro Assessment

Reduced impact of a tobacco product was observed on the smoking “field-of-injury” tissues.

scholarly journals Comparative effects of a candidate modified-risk tobacco product Aerosol and cigarette smoke on human organotypic small airway cultures: a systems toxicology approach

2017 ◽  
Vol 6 (6) ◽  
pp. 930-946 ◽  
Author(s):  
Anita R. Iskandar ◽  
Yannick Martinez ◽  
Florian Martin ◽  
Walter K. Schlage ◽  
Patrice Leroy ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Heating System ◽  
Tobacco Product ◽  
Small Airway ◽  
Biological Impact ◽  
Systems Toxicology

The biological impact of a tobacco heating system 2.2 aerosol and cigarette smoke were compared.

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