Catalytic activity of hammerhead ribozymes in a clay mineral environment: Implications for the RNA world

Gene ◽  
2007 ◽  
Vol 389 (1) ◽  
pp. 10-18 ◽  
Author(s):  
Elisa Biondi ◽  
Sergio Branciamore ◽  
Luca Fusi ◽  
Selma Gago ◽  
Enzo Gallori
Keyword(s):  
Catalytic Activity ◽  
Clay Mineral ◽  
Rna World ◽  
Hammerhead Ribozymes

scholarly journals Pyrene modification leads to increased catalytic activity in minimal hammerhead ribozymes

2007 ◽  
pp. 4357 ◽  
Author(s):  
Verena Looser ◽  
Simon M. Langenegger ◽  
Robert Häner ◽  
Jörg S. Hartig
Keyword(s):  
Catalytic Activity ◽  
Hammerhead Ribozymes

scholarly journals Minimal Hammerhead Ribozymes with Uncompromised Catalytic Activity

2015 ◽  
Vol 427 (14) ◽  
pp. 2340-2347 ◽  
Author(s):  
Sara M. O'Rourke ◽  
William Estell ◽  
William G. Scott
Keyword(s):  
Catalytic Activity ◽  
Hammerhead Ribozymes

MODIFIED BINARY HAMMERHEAD RIBOZYMES WITH HIGH CATALYTIC ACTIVITY

2005 ◽  
Vol 24 (5-7) ◽  
pp. 1105-1109 ◽  
Author(s):  
M. Vorobjeva ◽  
E. Gusseva ◽  
M. Repkova ◽  
N. Kovalev ◽  
M. Zenkova ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
High Catalytic Activity ◽  
Hammerhead Ribozymes

scholarly journals The influence of imperfectly paired helices I and III on the catalytic activity of hammerhead ribozymes

1994 ◽  
Vol 22 (24) ◽  
pp. 5271-5278 ◽  
Author(s):  
Michalis Zoumadakis ◽  
Wolfgang J. Neubert ◽  
Martin Tabler
Keyword(s):  
Catalytic Activity ◽  
Hammerhead Ribozymes

scholarly journals A Prebiotic Ribosylation of Pyrimidine Nucleobases Promoted by Metal Cations and Clay Minerals

2021 ◽  
Author(s):  
Qian-Qian Chen ◽  
Ze-Run Zhao ◽  
Xiao Wang
Keyword(s):  
Clay Minerals ◽  
Clay Mineral ◽  
Rna World ◽  
Metal Cations ◽  
Clay Model ◽  
World Hypothesis ◽  
Metal Doped ◽  
Rna World Hypothesis ◽  
Selection Of

We report a prebiotically relevant solution to the N1-ribosylation of pyrimidine nucleobases, a well-known challenge in the RNA World hypothesis. It is found that the presence of metal cations and clay mineral enables the previously unachievable direct ribosylation of uracil, providing by far the highest yield. Spectroscopy and chromatography analyses confirmed the formation of ribosylated uracil. The method can also be extended to the ribosylation of 2-pyrimidinone. These findings are also compatible with the metal-doped-clay model developed by our lab for the unified route of the selection of ribose and subsequent syntheses of nucleotide and RNA.

New Structural Motifs for Hammerhead Ribozymes. Catalytic Activity of Abasic Nucleotide Substituted Ribozymes

1995 ◽  
Vol 14 (3) ◽  
pp. 907-910 ◽  
Author(s):  
Leonid Beigelman ◽  
Alexander Karpeisky ◽  
Jasenka Matulic-Adamic ◽  
Carolyn Gonzalez ◽  
Nassim Usman
Keyword(s):  
Catalytic Activity ◽  
Hammerhead Ribozymes ◽  
Structural Motifs

Catalytic activity of an iron-pillared montmorillonitic clay mineral in heterogeneous photo-Fenton process

2008 ◽  
Vol 133-135 ◽  
pp. 600-605 ◽  
Author(s):  
María A. De León ◽  
Jorge Castiglioni ◽  
Juan Bussi ◽  
Marta Sergio
Keyword(s):  
Catalytic Activity ◽  
Clay Mineral ◽  
Fenton Process ◽  
Montmorillonitic Clay
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