Lessons Learned from the First Clinical Trial to Compare Outcomes of Lungs Transplanted from Uncontrolled Donation After Circulatory Determination of Death Donors (uDCDDs) Assessed by Ex-Vivo Lung Perfusion (EVLP) and CT Scan and Lungs Transplanted from Conventional Donors (CONV)

2017 ◽  
Vol 36 (4) ◽  
pp. S145
Author(s):  
T.M. Egan ◽  
J. Blackwell ◽  
B. Haithcock ◽  
J. Long ◽  
K. Birchard ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Ct Scan ◽  
Ex Vivo ◽  
Lung Perfusion ◽  
Lessons Learned ◽  
Determination Of Death ◽  
Ex Vivo Lung Perfusion

scholarly journals Custodiol-MP for ex vivo lung perfusion – A comparison in a porcine model of donation after circulatory determination of death

2021 ◽  
pp. 039139882199066
Author(s):  
Katharina Kalka ◽  
Zoe Keldenich ◽  
Henning Carstens ◽  
Björn Walter ◽  
Ursula Rauen ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Functional Outcomes ◽  
Porcine Model ◽  
Ex Vivo ◽  
Lung Perfusion ◽  
Determination Of Death ◽  
Ex Vivo Lung Perfusion ◽  
Lactate Dehydrogenase Activity ◽  
Lactate Levels

Introduction: Ex vivo lung perfusion (EVLP) is an established technique to evaluate and eventually recondition lungs prior to transplantation. Custodiol-MP (C-MP) solution is a new solution, designed for clinical machine perfusion, that has been used for kidneys. The aim of this study was to compare the effects of EVLP with Custodiol-MP on lung functional outcomes to the gold standard of EVLP with Steen Solution™. Material and Methods: In a porcine EVLP model of DCDD (Donation after Circulatory Determination of Death), lungs were perfused with Steen Solution™ (SS, n = 7) or Custodiol-MP solution supplemented with 55 g/l albumin (C-MP, n = 8). Lungs were stored cold for 4 h in low potassium dextran solution and subsequently perfused ex vivo for 4 h. During EVLP pulmonary gas exchange, activities of lactate dehydrogenase (LDH) and alkaline phosphatase (AP) as well as levels of lactate in the perfusate were recorded hourly. Results: Oxygenation capacity differed significantly between groups (averaged over 4 h: SS 274 ± 178 mmHg; C-MP 284 ± 151 mmHg p = 0.025). Lactate dehydrogenase activities and lactate concentrations were significantly lower in Custodiol-MP perfused lungs. In a porcine model of DCDD with 4 h of EVLP the use of modified Custodiol-MP as perfusion solution was feasible. The use of C-MP showed at least comparable lung functional outcomes to the use of Steen SolutionTM. Furthermore C-MP perfusion resulted in significantly lower lactate dehydrogenase activity and lactate levels in the perfusate and higher oxygenation capacity.

The NOVEL Study. A Multi-Center Clinical Trial Studying the Safety of Ex Vivo Lung Perfusion

2020 ◽  
Vol 39 (4) ◽  
pp. S110
Author(s):  
P.G. Sanchez ◽  
E. Cantu ◽  
M. Hartwig ◽  
F. D'Ovidio ◽  
T. Machuca ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Ex Vivo ◽  
Lung Perfusion ◽  
The Novel ◽  
Ex Vivo Lung Perfusion

Standard donor lung procurement with normothermic ex vivo lung perfusion: A prospective randomized clinical trial

2017 ◽  
Vol 36 (7) ◽  
pp. 744-753 ◽  
Author(s):  
Alexis Slama ◽  
Lukas Schillab ◽  
Maximilian Barta ◽  
Aris Benedek ◽  
Andreas Mitterbauer ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Ex Vivo ◽  
Lung Perfusion ◽  
Ex Vivo Lung Perfusion ◽  
Prospective Randomized Clinical Trial ◽  
Donor Lung

Assessing Human Lungs Unsuitable for Transplant By Ex-Vivo Lung Perfusion (EVLP) and Ex-Vivo CT Scan: Does EVLP Cause Inflammation?

2015 ◽  
Vol 34 (4) ◽  
pp. S139
Author(s):  
T.M. Egan ◽  
B. Dong ◽  
J. Blackwell ◽  
K. Birchard ◽  
P. Stewart ◽  
...  
Keyword(s):  
Ct Scan ◽  
Ex Vivo ◽  
Lung Perfusion ◽  
Ex Vivo Lung Perfusion ◽  
Human Lungs
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