Third Annual Report From the ISHLT Mechanically Assisted Circulatory Support Registry: A comparison of centrifugal and axial continuous-flow left ventricular assist devices

2019 ◽  
Vol 38 (4) ◽  
pp. 352-363 ◽  
Author(s):  
Daniel J. Goldstein ◽  
Bart Meyns ◽  
Rongbing Xie ◽  
Jennifer Cowger ◽  
Stephen Pettit ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Annual Report ◽  
Left Ventricular ◽  
Ventricular Assist Devices ◽  
Circulatory Support ◽  
Left Ventricular Assist Devices ◽  
Ventricular Assist ◽  
Assist Devices ◽  
Left Ventricular Assist

scholarly journals Endocrine Challenges in Patients with Continuous-Flow Left Ventricular Assist Devices

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 861
Author(s):  
Gennaro Martucci ◽  
Federico Pappalardo ◽  
Harikesh Subramanian ◽  
Giulia Ingoglia ◽  
Elena Conoscenti ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Left Ventricular ◽  
Endocrine Function ◽  
Ventricular Assist Devices ◽  
Circulatory Support ◽  
Endocrine Dysfunction ◽  
Left Ventricular Assist Devices ◽  
Ventricular Assist ◽  
Assist Devices ◽  
Left Ventricular Assist

Heart failure (HF) remains a leading cause of morbidity, hospitalization, and mortality worldwide. Advancement of mechanical circulatory support technology has led to the use of continuous-flow left ventricular assist devices (LVADs), reducing hospitalizations, and improving quality of life and outcomes in advanced HF. Recent studies have highlighted how metabolic and endocrine dysfunction may be a consequence of, or associated with, HF, and may represent a novel (still neglected) therapeutic target in the treatment of HF. On the other hand, it is not clear whether LVAD support, may impact the outcome by also improving organ perfusion as well as improving the neuro-hormonal state of the patients, reducing the endocrine dysfunction. Moreover, endocrine function is likely a major determinant of human homeostasis, and is a key issue in the recovery from critical illness. Care of the endocrine function may contribute to improving cardiac contractility, immune function, as well as infection control, and rehabilitation during and after a LVAD placement. In this review, data on endocrine challenges in patients carrying an LVAD are gathered to highlight pathophysiological states relevant to this setting of patients, and to summarize the current therapeutic suggestions in the treatment of thyroid dysfunction, and vitamin D, erythropoietin and testosterone administration.

scholarly journals Tolerance of Sustained Ventricular Fibrillation During Continuous-Flow Left Ventricular Assist Device Support

2017 ◽  
Vol 44 (5) ◽  
pp. 357-360 ◽  
Author(s):  
Andrew C.W. Baldwin ◽  
Courtney J. Gemmato ◽  
Elena Sandoval ◽  
William E. Cohn ◽  
Jeffrey A. Morgan ◽  
...  
Keyword(s):  
Ventricular Fibrillation ◽  
Continuous Flow ◽  
Mechanical Circulatory Support ◽  
Left Ventricular ◽  
Ventricular Assist Devices ◽  
Circulatory Support ◽  
Left Ventricular Assist Devices ◽  
Ventricular Assist ◽  
Assist Devices ◽  
Left Ventricular Assist

The widespread use of continuous-flow left ventricular assist devices for mechanical circulatory support has shown that long-term hemodynamic support is possible, even when a clinical “pulse” cannot be detected. We present the incidental discovery of ventricular fibrillation in 6 alert, hemodynamically stable patients supported only by a continuous-flow device (HeartMate II, n=5; Jarvik 2000, n=1). Ventricular fibrillation was found in 3 patients during routine outpatient follow-up visits and in 3 awaiting discharge from the hospital after device placement. Diagnosis was confirmed by electrocardiographic and echocardiographic studies. The average duration of mechanical circulatory support before ventricular fibrillation occurred was 221 ± 362 days (range, 5–864 d). All patients were conscious and ambulatory at the time of the arrhythmia. Three patients reported symptoms—primarily fatigue, nausea, and exertional dyspnea—that prompted evaluation. Serum chemistry analysis of blood drawn immediately after diagnosis showed no changes that suggested end-organ dysfunction. Three patients died of unrelated complications an average of 3.9 yr (range, 360–2,270 d) after the event. Two of the remaining 3 patients eventually underwent successful pump explantation, and one is on ongoing support. Our experience shows that it is possible for patients with continuous-flow left ventricular assist devices to remain hemodynamically stable while in ventricular fibrillation. Additional investigation is needed to determine whether defibrillator settings for these patients should be adjusted to limit delivery of shock therapy.

Bridging to transplantation with continuous flow left ventricular assist devices: The Vienna 9-year experience

2008 ◽  
Vol 56 (S 1) ◽  
Author(s):  
S Sandner ◽  
D Zimpfer ◽  
P Zrunek ◽  
B Steinlechner ◽  
A Rajek ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Left Ventricular ◽  
Ventricular Assist Devices ◽  
Left Ventricular Assist Devices ◽  
Ventricular Assist ◽  
Assist Devices ◽  
Left Ventricular Assist

Immunologic effects of continuous-flow left ventricular assist devices before and after heart transplant

2016 ◽  
Vol 35 (8) ◽  
pp. 1024-1030 ◽  
Author(s):  
Byung-Soo Ko ◽  
Stavros Drakos ◽  
Abdallah G. Kfoury ◽  
Denise Hurst ◽  
Gregory J. Stoddard ◽  
...  
Keyword(s):  
Heart Transplant ◽  
Continuous Flow ◽  
Left Ventricular ◽  
Ventricular Assist Devices ◽  
Left Ventricular Assist Devices ◽  
Ventricular Assist ◽  
Assist Devices ◽  
Left Ventricular Assist ◽  
Before And After

scholarly journals Effects on pre- and posttransplant pulmonary hemodynamics in patients with continuous-flow left ventricular assist devices

2010 ◽  
Vol 140 (2) ◽  
pp. 447-452 ◽  
Author(s):  
Ranjit John ◽  
Kenneth Liao ◽  
Forum Kamdar ◽  
Peter Eckman ◽  
Andrew Boyle ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Left Ventricular ◽  
Ventricular Assist Devices ◽  
Left Ventricular Assist Devices ◽  
Pulmonary Hemodynamics ◽  
Ventricular Assist ◽  
Assist Devices ◽  
Left Ventricular Assist
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