Well-differentiated hepatocellular neoplasm of uncertain malignant potential: proposal for a new diagnostic category

2014 ◽  
Vol 45 (3) ◽  
pp. 658-660 ◽  
Author(s):  
Pierre Bedossa ◽  
Alastair D. Burt ◽  
Elizabeth M. Brunt ◽  
Francesco Callea ◽  
Andrew D. Clouston ◽  
...  
2011 ◽  
Vol 18 (5) ◽  
pp. 579-594 ◽  
Author(s):  
Sandra Lassalle ◽  
Véronique Hofman ◽  
Marius Ilie ◽  
Christelle Bonnetaud ◽  
Marie-Pierre Puisségur ◽  
...  

The term ‘thyroid tumors of uncertain malignant potential’ (TT-UMP) was coined by surgical pathologists to define well-differentiated tumors (WDT) showing inconclusive morphological evidence of malignancy or benignity. We have analyzed the expression of microRNA (miRNA) in a training set of 42 WDT of different histological subtypes: seven follicular tumors of UMP (FT-UMP), six WDT-UMP, seven follicular thyroid adenomas (FTA), 11 conventional papillary thyroid carcinomas (C-PTC), five follicular variants of PTC (FV-PTC), and six follicular thyroid carcinomas (FTC), which led to the identification of about 40 deregulated miRNAs. A subset of these altered miRNAs was independently validated by qRT-PCR, which included 18 supplementary TT-UMP (eight WDT-UMP and ten FT-UMP). Supervised clustering techniques were used to predict the first 42 samples. Based on the four possible outcomes (FTA, C-PTC, FV-PTC, and FTC), about 80% of FTA and C-PTC and 50% of FV-PTC and FTC samples were correctly assigned. Analysis of the independent set of 18 WDT-UMP by quantitative RT-PCR for the selection of the six most discriminating miRNAs was unable to separate FT-UMP from WDT-UMP, suggesting that the miRNA signature is insufficient in characterizing these two clinical entities. We conclude that considering FT-UMP and WDT-UMP as distinct and specific clinical entities may improve the diagnosis of WDT of the thyroid gland. In this context, a small set of miRNAs (i.e. miR-7, miR-146a, miR-146b, miR-200b, miR-221, and miR-222) appears to be useful, though not sufficient per se, in distinguishing TT-UMP from other WDT of the thyroid gland.


2015 ◽  
Vol 10 (1) ◽  
Author(s):  
Monika Lamba Saini ◽  
Birgit Weynand ◽  
Jacques Rahier ◽  
Michel Mourad ◽  
Marc Hamoir ◽  
...  

2015 ◽  
Vol 46 (4) ◽  
pp. 634-635 ◽  
Author(s):  
Charles Balabaud ◽  
Paulette Bioulac-Sage ◽  
Linda Ferrell ◽  
Sanjay Kakar ◽  
Valérie Paradis ◽  
...  

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