Diagnostic value of HBME-1 and CK19 expression in papillary thyroid carcinoma, well-differentiated tumors of uncertain malignant potential, and benign thyroid nodules

Aim: To investigate the clinical roles of LINC00152 and SNHG12 in papillary thyroid carcinoma (PTC). Methods: LINC00152 and SNHG12 expression was sought and analysis in gene expression omnibus, The Cancer Genome Atlas and GEPIA datasets. Tumor and adjacent normal tissues were collected from 97 PTC and 44 benign thyroid nodules patients. The expression was evaluated by quantitative real-time polymerase chain reaction. The association between the expression level and clinicopathologic characteristics was analyzed by χ2 test. Receiver operating characteristic curves were plotted to evaluate the diagnostic value. Results: The expression of SNHG12 and LINC00152 were significantly higher in PTC tissues than in adjacent normal tissues not only in gene expression omnibus database but the validated samples. More interesting, LINC00152 expression level was also significantly higher in PTC tissues than that in benign thyroid nodules. The upregulation of LINC00152 and SNHG12 was associated with the malignant progression of PTC. Receiver operating characteristic curve analysis also demonstrated that there was a good trend, which indicates that they may have certain diagnostic value. Conclusion: LINC00152 and SNHG12 might serve as serve as potential related molecules of PTC.

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T2* mapping at 3.0T MRI for differentiation of papillary thyroid carcinoma from benign thyroid nodules

Journal of Magnetic Resonance Imaging ◽

10.1002/jmri.25041 ◽

2015 ◽

Vol 43 (4) ◽

pp. 956-961 ◽

Cited By ~ 4

Author(s):

Ruoyang Shi ◽

Qiuying Yao ◽

Lianming Wu ◽

Qinyi Zhou ◽

Qing Lu ◽

...

Keyword(s):

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Thyroid Nodules ◽

T2 Mapping ◽

Papillary Thyroid ◽

3.0T Mri ◽

Benign Thyroid Nodules ◽

Benign Thyroid

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Immunohistochemical Study of Papillary Thyroid Carcinoma and Possible Papillary Thyroid Carcinoma-related Benign Thyroid Nodules

Pathology - Research and Practice ◽

10.1016/s0344-0338(00)80025-4 ◽

2000 ◽

Vol 196 (8) ◽

pp. 533-540 ◽

Cited By ~ 17

Author(s):

Kien T. Mai ◽

Jason C. Ford ◽

Hossein M. Yazdi ◽

D. Garth Perkins ◽

A. Susan Commons

Keyword(s):

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Thyroid Nodules ◽

Immunohistochemical Study ◽

Papillary Thyroid ◽

Benign Thyroid Nodules ◽

Benign Thyroid

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Altered expression of DLG1-AS1 distinguished papillary thyroid carcinoma from benign thyroid nodules

BMC Endocrine Disorders ◽

10.1186/s12902-019-0440-x ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 2

Author(s):

Tao He ◽

Huan Wang ◽

Jiangming Sun ◽

Jie Wu ◽

Fakuo Gong ◽

...

Keyword(s):

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Thyroid Nodules ◽

Curve Analysis ◽

Healthy Controls ◽

Papillary Thyroid ◽

Roc Curve Analysis ◽

Altered Expression ◽

Benign Thyroid Nodules ◽

Benign Thyroid

Abstract Background Benign thyroid nodules (BTN) are frequently diagnosed as papillary thyroid carcinoma (PTC), leading to unnecessary treatment. We found that plasma lncRNA DLG1-AS1 was upregulated in PTC patients but not in BTN patients and healthy controls. Methods In this study DLG1-AS1 and miR-199a-3p in plasma of both PTC patients and BTN patients were detected by qPCR. ROC curve analysis was performed for diagnostic analysis. Overexpression experiments were performed to analyze the interaction between DLG1-AS1 and miR-199a-3p. CCK-8 assay was performed to analyze cell proliferation. Results In this study, upregulation of DLG1-AS1 distinguished PTC patients from BTN patients and healthy controls. Plasma miR-199a-3p was downregulated in PTC patients compared with healthy controls and BTN patients. Plasma levels of miR-199a-3p were inversely correlated in PTC patients, but not in BTN patients and healthy controls. miR-199a-3p overexpression failed to significantly affect DLG1-AS1, while DLG1-AS1 overexpression resulted in downregulated miR-199a-3p, In addition, DLG1-AS1 overexpression promoted the proliferation of PTC cells. miR-199a-3p overexpression played an opposite role and attenuated the effects of DLG1-AS1 overexpression. Conclusions Therefore, DLG1-AS1 may promote PTC by downregulating miR-199a-3p.

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Re-Evaluation of 162 Malignant Thyroid Nodules that were Interpreted as Benign Based on Ultrasound Findings

Ultrasound International Open ◽

10.1055/a-0732-5795 ◽

2018 ◽

Vol 4 (04) ◽

pp. E110-E116

Author(s):

Tomoko Fujimoto ◽

Mitsuyoshi Hirokawa ◽

Ayana Suzuki ◽

Hisashi Ota ◽

Maki Oshita ◽

...

Keyword(s):

Papillary Thyroid Carcinoma ◽

Thyroid Nodules ◽

Pathological Features ◽

Pathological Findings ◽

Papillary Thyroid ◽

Thyroid Ultrasonography ◽

Ultrasound Findings ◽

Oxyphilic Cell ◽

Benign Thyroid Nodules ◽

Benign Thyroid

AbstractThe goal of this study was to estimate the risk of malignant thyroid nodules being interpreted as benign based on ultrasound findings and to clarify the pathological features of these malignant nodules. We retrospectively re-evaluated ultrasound and pathological findings for 162 malignant thyroid nodules that were initially interpreted as benign based on ultrasound findings at Kuma Hospital between April 2012 and June 2015.The incidences of malignancy among “benign” thyroid nodules were 0.5% overall and 6.2% among resected nodules. In addition, 82.7% of thyroid nodules that were originally judged to have low or very low suspicion patterns were subsequently re-categorized as having high or intermediate suspicion patterns. The incidences of irregular margins (63.6%) and low echogenicity (36.4%) were higher than those of punctate microcalcification (17.9%) and the taller-than-wide shape (20.4%). Among microcarcinomas, the incidences were 65.7% for irregular margins and 51.4% for low echogenicity. Rim calcification with small extrusive soft tissue components and extrathyroidal extensions were not observed. After re-evaluation, 40.0% of papillary thyroid carcinomas remained benign based on their variants, such as the encapsulated, follicular, macrofollicular, and oxyphilic cell variants. We conclude that more careful observation, especially for lesions with irregular margins and low echogenicity, can help improve the diagnostic accuracy of thyroid ultrasonography. Furthermore, greater care may decrease the incidence of malignancy among thyroid nodules with low or very low suspicion patterns. Some variants of papillary thyroid carcinoma can have benign ultrasound findings.

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