α-Bisabolol from Chamomile – A specific ergosterol biosynthesis inhibitor?

2006 ◽  
Vol 16 (1) ◽  
pp. 21-25 ◽  
Author(s):  
A PAULI
Keyword(s):  
Ergosterol Biosynthesis ◽  
Biosynthesis Inhibitor

scholarly journals Comparative Efficacies of TAK-187, a Long-Lasting Ergosterol Biosynthesis Inhibitor, and Benznidazole in Preventing Cardiac Damage in a Murine Model of Chagas' Disease

2005 ◽  
Vol 49 (4) ◽  
pp. 1556-1560 ◽  
Author(s):  
Milagros Corrales ◽  
Rubén Cardozo ◽  
María Asunción Segura ◽  
Julio A. Urbina ◽  
Miguel Angel Basombrío
Keyword(s):  
Trypanosoma Cruzi ◽  
Comparative Study ◽  
Chagas Disease ◽  
Murine Model ◽  
Ergosterol Biosynthesis ◽  
Cardiac Damage ◽  
Experimental Animals ◽  
Biosynthesis Inhibitor

ABSTRACT We carried out a comparative study of benznidazole and TAK-187, a long-lasting ergosterol biosynthesis inhibitor, with a murine model of Chagas' disease. The results indicated that TAK-187 was more effective than benznidazole in preventing Trypanosoma cruzi-induced cardiac damage in experimental animals.

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