Impact of rasagiline nanoparticles on brain targeting efficiency via gellan gum based transdermal patch: A nanotheranostic perspective for Parkinsonism

2020 ◽  
Vol 164 ◽  
pp. 1006-1024 ◽  
Author(s):  
Nikhil R. Bali ◽  
Pramod S. Salve
Keyword(s):  
Gellan Gum ◽  
Brain Targeting ◽  
Transdermal Patch ◽  
Targeting Efficiency

scholarly journals Brain targeting efficiency of intranasal clozapine-loaded mixed micelles following radio labeling with Technetium-99m

Drug Delivery ◽  
2021 ◽  
Vol 28 (1) ◽  
pp. 1524-1538
Author(s):  
Sinar Sayed ◽  
Fatma M. Elsharkawy ◽  
Maha M. Amin ◽  
Hesham A. Shamsel-Din ◽  
Ahmed B. Ibrahim
Keyword(s):  
Mixed Micelles ◽  
Brain Targeting ◽  
Technetium 99M ◽  
Targeting Efficiency ◽  
Radio Labeling

scholarly journals Formulation and optimization of coated PLGA – Zidovudine nanoparticles using factorial design and in vitro in vivo evaluations to determine brain targeting efficiency

2014 ◽  
Vol 22 (2) ◽  
pp. 133-140 ◽  
Author(s):  
G.V. Peter Christoper ◽  
C. Vijaya Raghavan ◽  
K. Siddharth ◽  
M. Siva Selva Kumar ◽  
R. Hari Prasad
Keyword(s):  
Factorial Design ◽  
Brain Targeting ◽  
Targeting Efficiency

Preparation of surface multiple-coated polylactide acid drug-loaded nanoparticles for intranasal delivery and evaluation on its brain-targeting efficiency

Drug Delivery ◽  
2014 ◽  
Vol 23 (1) ◽  
pp. 269-276 ◽  
Author(s):  
Junjie Bian ◽  
Zhixiang Yuan ◽  
Xiaoliang Chen ◽  
Yuan Gao ◽  
Chaoqun Xu ◽  
...  
Keyword(s):  
Brain Targeting ◽  
Intranasal Delivery ◽  
Targeting Efficiency ◽  
Polylactide Acid

Formulation of intranasal mucoadhesive temperature-mediatedin situgel containing ropinirole and evaluation of brain targeting efficiency in rats

2009 ◽  
Vol 18 (3) ◽  
pp. 223-234 ◽  
Author(s):  
Shagufta Khan ◽  
Kundan Patil ◽  
Nishan Bobade ◽  
Pramod Yeole ◽  
Rajiv Gaikwad
Keyword(s):  
Brain Targeting ◽  
Targeting Efficiency

Brain targeting efficiency of antimigrain drug loaded mucoadhesive intranasal nanoemulsion

2017 ◽  
Vol 529 (1-2) ◽  
pp. 667-677 ◽  
Author(s):  
Ebtsam M. Abdou ◽  
Soha M. Kandil ◽  
Hala M.F. El Miniawy
Keyword(s):  
Brain Targeting ◽  
Targeting Efficiency

scholarly journals Formulation development and characterization of in-situ gel of Rizatriptan Benzoate for intranasal delivery

2021 ◽  
Vol 11 (1-s) ◽  
pp. 1-6
Author(s):  
Jalaram H Thakkar ◽  
Shailesh T. Prajapati
Keyword(s):  
Ex Vivo ◽  
Gellan Gum ◽  
Brain Targeting ◽  
Great Promise ◽  
Formulation Development ◽  
In Situ Gel ◽  
Rizatriptan Benzoate ◽  
32 Factorial Design

The present investigation was aimed to formulate and characterize ion-activated in-situ gel loaded with Rizatriptan Benzoate (RIZ) for intranasal administration for brain targeting. The gel was further optimized for process and formulation parameters by using 32 factorial design. The optimized batch having the concentrations of gellan gum and HPMC E15 LV 33.83 mg and 9.6 mg respectively. Gel strength and mucoadhesive strength of the optimized formulation were found to be 32.54 sec and 2580.50 dynes/cm2 respectively. Moreover, improved in-vitro and ex-vivo release profile of in-situ gel were observed in comparison to drug solution. In a nutshell, the developed formulation holds a great promise in overcoming the limitation associated with currently marketed RIZ formulations and illustrates the potential use of ion-activated in-situ gel to administer the drug by nasal route for brain targeting. Keywords: In-situ gel, Rizatriptan benzoate, Ion-activated, Gellan gum, HPMC E15 LV, Brain delivery, Migraine

Brain targeting efficiency of Curcumin loaded mucoadhesive microemulsion through intranasal route

2016 ◽  
Vol 46 (2) ◽  
pp. 179-188 ◽  
Author(s):  
Snigdha Das Mandal ◽  
Surjyanarayan Mandal ◽  
Jayvadan Patel
Keyword(s):  
Brain Targeting ◽  
Intranasal Route ◽  
Targeting Efficiency
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