gellan gum
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Bioprinting ◽  
2022 ◽  
Vol 25 ◽  
pp. e00185
Author(s):  
Hatai Jongprasitkul ◽  
Sanna Turunen ◽  
Vijay Singh Parihar ◽  
Minna Kellomäki
Keyword(s):  

2022 ◽  
pp. 088532822110527
Author(s):  
Piotr Gadziński ◽  
Tomasz Zbigniew Osmałek ◽  
Anna Froelich ◽  
Oliwia Wilmańska ◽  
Agata Nowak ◽  
...  

Purpose. In the performed study, the rheological and textural parameters of gellan-based hydrogels were investigated and their dependence on three factors was taken into consideration: ( i) The presence of the model drug, ( ii) The presence and type of the ionic crosslinking agent, and ( iii) the composition of the polymer network. The objective was to compare two analytical methods, regarded as complementary, and define to what extent the obtained results correlate with each other. Methods. The hydrogels contained low-acyl gellan gum or its mixtures with hydroxyethyl cellulose or κ-carrageenan. CaCl2 and MgCl2 were used as gelling agents. Mesalazine was used as a model drug. The rheological analysis included oscillatory stress and frequency sweeping. The texture profile analysis was performed to calculate texture parameters. Results. Placebo gels without the addition of gelling agents had the weakest structure. The drug had the strongest ability to increase the stiffness of the polymer network. The weakest structure revealed the placebo samples without the addition of gelling agents. Texture analysis revealed no significant influence of the drug on the strength of the gels, while rheological measurements indicated clear differences. Conclusions. It can be concluded that in the case of some parameters methods correlate, that is, the effect related to gelling ions. However, the rheological analysis seems to be more precise and sensitive to some changes in the mechanical properties of the gels.


2022 ◽  
pp. 107487
Author(s):  
Linyuan Liu ◽  
Duoduo Zhang ◽  
Xiaoxiao Song ◽  
Mi Guo ◽  
Ziwei Wang ◽  
...  

2022 ◽  
Vol 53 ◽  
Author(s):  
Amanda Rodrigues Leal ◽  
Luciana de Siqueira Oliveira ◽  
Juliana Nascimento da Costa ◽  
Carlos Artur Nascimento Alves ◽  
Paulina Mata ◽  
...  

2021 ◽  
Vol 23 (1) ◽  
pp. 321
Author(s):  
Katarzyna Reczyńska-Kolman ◽  
Kinga Hartman ◽  
Konrad Kwiecień ◽  
Monika Brzychczy-Włoch ◽  
Elżbieta Pamuła

Due to growing antimicrobial resistance to antibiotics, novel methods of treatment of infected wounds are being searched for. The aim of this research was to develop a composite wound dressing based on natural polysaccharides, i.e., gellan gum (GG) and a mixture of GG and alginate (GG/Alg), containing lipid nanoparticles loaded with antibacterial peptide—nisin (NSN). NSN-loaded stearic acid-based nanoparticles (NP_NSN) were spherical with an average particle size of around 300 nm and were cytocompatible with L929 fibroblasts for up to 500 µg/mL. GG and GG/Alg sponges containing either free NSN (GG + NSN and GG/Alg + NSN) or NP_NSN (GG + NP_NSN and GG/Alg + NP_NSN) were highly porous with a high swelling capacity (swelling ratio above 2000%). Encapsulation of NSN within lipid nanoparticles significantly slowed down NSN release from GG-based samples for up to 24 h (as compared to GG + NSN). The most effective antimicrobial activity against Gram-positive Streptococcus pyogenes was observed for GG + NP_NSN, while in GG/Alg it was decreased by interactions between NSN and Alg, leading to NSN retention within the hydrogel matrix. All materials, except GG/Alg + NP_NSN, were cytocompatible with L929 fibroblasts and did not cause an observable delay in wound healing. We believe that the developed materials are promising for wound healing application and the treatment of bacterial infections in wounds.


Author(s):  
Amanda Rodrigues LEAL ◽  
Luiz Eduardo Oliveira HOLANDA ◽  
Fernanda Clara Moreira SOARES ◽  
Juliana Nascimento da COSTA ◽  
Luís Gustavo Lima NASCIMENTO ◽  
...  

2021 ◽  
pp. 33-61
Author(s):  
Joseph P. Sweety ◽  
Nandakumar Selvasudha ◽  
Unnikrishnan M. Dhanalekshmi ◽  
Nagarajan Sridurgadevi

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