Drug Delivery
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2021 ◽  
Vol 25 ◽  
pp. 101199
Bogdan V. Parakhonskiy ◽  
Natalia Yu Shilyagina ◽  
Оlga I. Gusliakova ◽  
Artur B. Volovetskiy ◽  
Alexey B. Kostyuk ◽  

2021 ◽  
Vol 9 ◽  
Man Zhou ◽  
Yan Luo ◽  
Weijia Zeng ◽  
Xiaoqing Yang ◽  
Tingting Chen ◽  

Chemotherapy is one of the commonly used therapies for the treatment of malignant tumors. Insufficient drug-loading capacity is the major challenge for polymeric micelle–based drug delivery systems of chemotherapy. Here, the redox-responsive star-shaped polymeric prodrug (PSSP) and the dimeric prodrug of paclitaxel (PTX) were prepared. Then the dimeric prodrug of PTX (diPTX, diP) was loaded into the core of the star-shaped polymeric prodrug micelles of PSSP by hydrophobic interaction forming the redox-responsive prodrug micelles of [email protected] for intracellular drug release in tumor cells. The hydrodynamic diameter of [email protected] nanoparticles was 114.3 nm ± 2.1 (PDI = 0.219 ± 0.016), and the micelles had long-term colloidal stability and the drug-loading content (DLC) of diPTX and PTX is 16.7 and 46.9%, respectively. The prepared micelles could broke under the reductive microenvironment within tumor cells, as a result, the dimeric prodrug of diP and polymeric prodrug micelles of PSSP were rapidly disassembled, leading to the rapid release of intracellular drugs. In vitro release studies showed that under the condition of reduced glutathione (GSH) (10 mM), the release of PTX was significantly accelerated with approximately 86.6% released within 21 h, and the released PTX in cytoplasm could promote the disintegration of microtubules and induce cell apoptosis. These results indicated that the new type of this reduction-sensitive nanodrug delivery system based on dimeric [email protected] prodrug micelles would be a promising technology in chemotherapy.

Nanomaterials ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 2790
Lina Jia ◽  
Peng Zhang ◽  
Hongyan Sun ◽  
Yuguo Dai ◽  
Shuzhang Liang ◽  

Nanoparticle delivery systems have good application prospects in the treatment of various diseases, especially in cancer treatment. The effect of drug delivery is regulated by the properties of nanoparticles. There have been many studies focusing on optimizing the structure of nanoparticles in recent years, and a series of achievements have been made. This review summarizes the optimization strategies of nanoparticles from three aspects—improving biocompatibility, increasing the targeting efficiency of nanoparticles, and improving the drug loading rate of nanoparticles—aiming to provide some theoretical reference for the subsequent drug delivery of nanoparticles.

2021 ◽  
Vol 22 (21) ◽  
pp. 11353
Mateusz Pawlaczyk ◽  
Grzegorz Schroeder

The following research aims at the synthesis of magnetite nanoparticles functionalized with triazine-based dendrons and the application of the obtained materials as effective sorptive materials dedicated to acidic bioactive compounds. The adopted synthetic approach involved: (1) the synthesis of nanosized Fe3O4 particles via classic co-precipitation method, (2) the introduction of amine groups on their surface leading to materials’ precursor, and (3) the final synthesis of branched triazine-based dendrons on the support surface by an iterative reaction between cyanuric chloride (CC) and piperazine (p) or diethylenetriamine (DETA) via nucleophilic substitution. The characterized materials were tested for their adsorptive properties towards folic acid, 18β–glycyrrhetinic acid, and vancomycin, showing high adsorption capacities varying in the ranges of 53.33–401.61, 75.82–223.71, and 68.17–132.45 mg g–1, respectively. The formed material–drug complexes were also characterized for the drug-delivery potential, performed as in vitro release studies at pH 2.0 and 7.4, which mimics the physiological conditions. The release profiles showed that the proposed materials are able to deliver up to 95.2% of the drugs within 48 h, which makes them efficient candidates for further biomedical applications.

Nanomedicine ◽  
2021 ◽  
Hari P Devkota ◽  
Keshav R Paudel ◽  
Niraj K Jha ◽  
Piyush K Gupta ◽  
Sachin K Singh ◽  

AIChE Journal ◽  
2021 ◽  
Ewa Dluska ◽  
Agnieszka Markowska‐Radomska ◽  
Agata Metera ◽  
Leszek Rudniak ◽  
Konrad Kosicki

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