scholarly journals Molecular biology technique combined with Fine needle aspiration cytology revealing the diagnostic dilemma in tubercular lymphadenitis cases

2016 ◽  
Vol 45 ◽  
pp. 152
Author(s):  
V. Gupta ◽  
A. Bhake
2018 ◽  
Vol 1 (2) ◽  
pp. 97-99
Author(s):  
Amar Narayan Shrestha ◽  
Shova Kunwar ◽  
Barun Babu Aryal ◽  
Anurag Adhikari ◽  
Ayusha Poudel

Introduction: Fine Needle Aspiration Cytology is a relatively simple, inexpensive and rapid diagnostic procedure for identifying cause of lymphadenopathy without need for surgical procedures. This study aims to explain the pattern of lymphadenopathy seen on fine needle aspiration cytology in a tertiary level hospital in KathmanduMaterials and Methods: This study was conducted at Shree Birendra Hospital Nepal. Cases of lymph node FNAC done in the years 2073 and 2074 BS were included in the study. The cases were classified into reactive lymphadenitis, granulomatous lymphadenitis, tubercular lymphadenitis, lymphomas, leukemias, and metastases.Results: A total of 215 patients were included in the study, ranging in age from 2 to 84 years, out of which 98 were female and 117 were male. Reactive lymphadenitis was the most common diagnosis (n=126; 58.6%), followed by granulomatous lymphadenitis (n=34; 15.8%) and tubercular lymphadenitis (n=18; 8.4%). There were 18 cases of metastatic malignancies, 15 cases of suppurative lymphadenitis, and 2 cases of Hodgkin lymphoma and 2 cases of non-Hodgkin lymphoma.Conclusions: Reactive lymphadenitis is the most common type of lymphadenopathy encountered in FNAC, while in the elderly, metastases are more common.


Author(s):  
Ashok Shreepaili ◽  
Sushil Dhakal

Background: Tuberculous lymphadenitis is the most common manifestation of extrapulmonary tuberculosis. Fine needle aspiration cytology (FNAC) is a valuable tool in diagnosis of tubercular lymphadenitis. The present study aims to determine the prevalence of different cytomorphological patterns in fine needle aspiration cytology of tubercular lymph nodes and their correlation with Acid Fast Bacilli (AFB) positivity on Ziehi-Neelsen (ZN) Staining.Methods: Fine needle aspiration cytology of 274 cases diagnosed as tubercular lymphadenitis over a period of a year were reviewed. Cytomorphological patterns were categorized into three patterns. Pattern I: Epithelioid granuloma without necrosis, Pattern II: Epithelioid granuloma with caseous necrosis and Pattern III: Caseous necrosis only. Fischer Exact test was applied to correlate cytomorphological pattern and AFB positivity.Results: Tuberculous lymphadenitis was most frequent in age group 21-30 years (24.81%). Cervical lymph nodes were the most frequent lymph nodes involved (84.67%). Pattern I was the most common cytomorphological pattern observed (49.3%). Overall AFB positivity was 28.10%. Maximum AFB positivity was seen in pattern III (73.3%).Conclusions: FNAC is the simple, cost effective and minimally invasive tool to diagnose tuberculous lymphadenitis. Study of both cytomorphological pattern and ZN staining for AFB can improve the diagnostic accuracy.


2014 ◽  
Vol 14 (4) ◽  
pp. 250 ◽  
Author(s):  
Ilker Burak Arslan ◽  
Sinan Uluyol ◽  
Selahattin Genc ◽  
Tugrul Eruyar ◽  
Suphi Bulgurcu ◽  
...  

2017 ◽  
Vol 5 (1) ◽  
pp. 22-23
Author(s):  
Suman Thapa ◽  
R. Parajuli ◽  
T. Limbu ◽  
R. Bhandari

Oncocytomas are rare benign tumors of salivary gland origin, most often seen involving the parotid gland. They should be considered as a possible diagnosis in elderly patients with slow growing, nontender and mobile parotid swelling. We report here a middle aged female with left parotid swelling that was misdiagnosed on fine needle aspiration cytology and confirmed with histopathology report. Rarity of the disease with frequent cytologic overlaps and interpreter’s inexperience account for the majority of aspiration cytology pitfalls. Therefore, aspiration cytology alone may be misguiding at times, leading to surgical over-correction and further potential complications. The ever-changing trends of mucoepidermoid carcinoma (pre-operative, fine needle aspiration cytology), pleomorphic adenoma (intraoperative) and oncocytoma (post-operative, histopathology) have created diagnostic dilemma, confusion and challenged the surgical rationale. In cases with discrepancy between clinical, cytological and pathological reports, diagnostic as well as surgical dilemma exists wherein a thorough diagnostic re-assessment and a proper surgical revision is warranted.  


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