Effect of the six-mer synthetic peptide (AT1002) fragment of zonula occludens toxin on the intestinal absorption of cyclosporin A

2008 ◽  
Vol 351 (1-2) ◽  
pp. 8-14 ◽  
Author(s):  
K SONG ◽  
A FASANO ◽  
N EDDINGTON
Keyword(s):  
Cyclosporin A ◽  
Intestinal Absorption ◽  
Synthetic Peptide ◽  
Zonula Occludens ◽  
Zonula Occludens Toxin

Human zonulin, a potential modulator of intestinal tight junctions

2000 ◽  
Vol 113 (24) ◽  
pp. 4435-4440 ◽  
Author(s):  
W. Wang ◽  
S. Uzzau ◽  
S.E. Goldblum ◽  
A. Fasano
Keyword(s):  
Tight Junction ◽  
Tight Junctions ◽  
Ussing Chamber ◽  
Intestinal Lumen ◽  
Epithelial Surface ◽  
Ussing Chambers ◽  
Zonula Occludens ◽  
Surface Receptor ◽  
Dynamic Structures ◽  
Zonula Occludens Toxin

Intercellular tight junctions are dynamic structures involved in vectorial transport of water and electrolytes across the intestinal epithelium. Zonula occludens toxin derived from Vibrio cholerae interacts with a specific intestinal epithelial surface receptor, with subsequent activation of a complex intracellular cascade of events that regulate tight junction permeability. We postulated that this toxin may mimic the effect of a functionally and immunologically related endogenous modulator of intestinal tight junctions. Affinity-purified anti-zonula occludens toxin antibodies and the Ussing chamber assay were used to screen for one or more mammalian zonula occludens toxin analogues in both fetal and adult human intestine. A novel protein, zonulin, was identified that induces tight junction disassembly in non-human primate intestinal epithelia mounted in Ussing chambers. Comparison of amino acids in the active zonula occludens toxin fragment and zonulin permitted the identification of the putative receptor binding domain within the N-terminal region of the two proteins. Zonulin likely plays a pivotal role in tight junction regulation during developmental, physiological, and pathological processes, including tissue morphogenesis, movement of fluid, macromolecules and leukocytes between the intestinal lumen and the interstitium, and inflammatory/autoimmune disorders.

Dissociation of ZO1-occludin complex is involved in zonula occludens toxin (Zot)-mediated disassembly of intestinal tight junctions

2001 ◽  
Vol 120 (5) ◽  
pp. A699
Author(s):  
Tammara L. Watts ◽  
Timothy D. Kiser ◽  
Regina A. Macatangay ◽  
Simeon E. Goldblum ◽  
Alessio Fasano
Keyword(s):  
Tight Junctions ◽  
Zonula Occludens ◽  
Zonula Occludens Toxin

scholarly journals Distribution of thezot(zonula occludens toxin) gene among strains ofVibrio cholerae01 and non-01

1993 ◽  
Vol 106 (2) ◽  
pp. 143-145 ◽  
Author(s):  
Tadahiro Karasawa ◽  
Tatsuya Mihara ◽  
Hisao Kurazono ◽  
G. Balakrish Nair ◽  
Surabhi Garg ◽  
...  
Keyword(s):  
Toxin Gene ◽  
Zonula Occludens ◽  
Zonula Occludens Toxin

FURTHER INSIGHT INTO PRODUCTION AND DIARRHEAGENICITY OF ZONULA OCCLUDENS TOXIN (ZOT) BY VIBRIO CHOLERAE

1991 ◽  
Vol 13 (3) ◽  
pp. 327
Author(s):  
A. Fasano ◽  
B. Baudry ◽  
J. B. Kaper ◽  
C. Ciarla ◽  
L. Ferraro ◽  
...  
Keyword(s):  
Vibrio Cholerae ◽  
Zonula Occludens ◽  
Zonula Occludens Toxin ◽  
Insight Into

scholarly journals In vitro evaluation of capsaicin inhibitory effects on zonula occludens toxin in vibrio cholerae ATCC14035 strain

2014 ◽  
Vol 2 (4) ◽  
pp. 33-35
Author(s):  
Soroor Erfanimanesh ◽  
Gita Eslami ◽  
Hossein Goudarzi ◽  
Arezou Taherpour ◽  
Ali Hashemi ◽  
...  
Keyword(s):  
Vibrio Cholerae ◽  
Inhibitory Effects ◽  
In Vitro Evaluation ◽  
Zonula Occludens ◽  
Zonula Occludens Toxin
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