Pharmacokinetics, tissue distribution and relative bioavailability of isoniazid-solid lipid nanoparticles

2013 ◽  
Vol 441 (1-2) ◽  
pp. 202-212 ◽  
Author(s):  
Rohit Bhandari ◽  
Indu Pal Kaur
Keyword(s):  
Tissue Distribution ◽  
Solid Lipid Nanoparticles ◽  
Relative Bioavailability ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Pharmacokinetics and Tissue Distribution of Idarubicin-Loaded Solid Lipid Nanoparticles After Duodenal Administration to Rats

2002 ◽  
Vol 91 (5) ◽  
pp. 1324-1333 ◽  
Author(s):  
Gian Paolo Zara ◽  
Alessandro Bargoni ◽  
Roberta Cavalli ◽  
Anna Fundarò ◽  
Daniela Vighetto ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Enhanced oral absorption of saquinavir mediated by PEGylated solid lipid nanoparticles

RSC Advances ◽  
2015 ◽  
Vol 5 (50) ◽  
pp. 40341-40347 ◽  
Author(s):  
Xiaoyu Hu ◽  
Xuqi Kang ◽  
Xiaoying Ying ◽  
Lejian Wang ◽  
Yongzhong Du
Keyword(s):  
Polyethylene Glycol ◽  
Solid Lipid Nanoparticles ◽  
Oral Absorption ◽  
Relative Bioavailability ◽  
Lipid Nanoparticles ◽  
Solid Lipid

PEGylated solid lipid nanoparticles containing saquinavir exhibited higher relative bioavailability which increased with enhancing of the polyethylene glycol content in the nanoparticles.

scholarly journals Pharmacokinetic and Tissue Distribution Study of Solid Lipid Nanoparticles of Zidovudine in Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Shah Purvin ◽  
Parameswara Rao Vuddanda ◽  
Sanjay Kumar Singh ◽  
Achint Jain ◽  
Sanjay Singh
Keyword(s):  
Oral Administration ◽  
Tissue Distribution ◽  
Solid Lipid Nanoparticles ◽  
High Performance ◽  
Lipid Nanoparticles ◽  
Peroral Administration ◽  
Pharmacokinetic Parameters ◽  
Distribution Study ◽  
Solid Lipid ◽  
Tissue Distribution Study

Zidovudine-loaded solid lipid nanoparticles (AZT-SLNs) and zidovudine in solution were prepared and administered in rats. The aim of this research was to study whether the bioavailability of zidovudine can be improved by AZT-SLNs perorally to rats as compared to oral administration of zidovudine. Zidovudine was determined in plasma and tissues by reverse phase high performance liquid chromatography. The pharmacokinetic parameters of zidovudine were determined after peroral administration: area under curve of concentration versus time (AUC) for AZT-SLNs was 31.25% greater than AZT solution; meanwhile mean resident time (MRT) was found to be 1.83 times higher for AZT-SLNs than AZT solution. Elimination half life of zidovudine was also increased for SLN formulation. Tissue distribution pattern of zidovudine was changed in case of AZT-SLNs. AUC of zidovudine in brain and liver was found to be approximately 2.73 and 1.77 times higher in AZT-SLNs than AZT solution, respectively, indicating that AZT-SLNs could cross blood brain barrier. Distribution of zidovudine was approximately 0.95 and 0.86 times lesser in heart and kidney, respectively. It can be concluded from the study that oral administration of AZT-SLNs modifies the plasma pharmacokinetic parameters and biodistribution of zidovudine.

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