Aerosolizable siRNA-encapsulated solid lipid nanoparticles prepared by thin-film freeze-drying for potential pulmonary delivery

2021 ◽  
Vol 596 ◽  
pp. 120215
Author(s):  
Jie-Liang Wang ◽  
Mahmoud S. Hanafy ◽  
Haiyue Xu ◽  
Jasmim Leal ◽  
Yufeng Zhai ◽  
...  
Keyword(s):  
Thin Film ◽  
Solid Lipid Nanoparticles ◽  
Freeze Drying ◽  
Pulmonary Delivery ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Inhalable Microparticles as Carriers for Pulmonary Delivery of Thymopentin-Loaded Solid Lipid Nanoparticles

2010 ◽  
Vol 27 (9) ◽  
pp. 1977-1986 ◽  
Author(s):  
Yan-Zhen Li ◽  
Xun Sun ◽  
Tao Gong ◽  
Jie Liu ◽  
Jiao Zuo ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Pulmonary Delivery ◽  
Lipid Nanoparticles ◽  
Solid Lipid

scholarly journals Biodistribution of Amikacin Solid Lipid Nanoparticles after Pulmonary Delivery

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
J. Varshosaz ◽  
S. Ghaffari ◽  
S. F. Mirshojaei ◽  
A. Jafarian ◽  
F. Atyabi ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Pulmonary Delivery ◽  
Lipid Nanoparticles ◽  
Free Drug ◽  
Male Rats ◽  
Sustained Drug Release ◽  
Drug Dosing ◽  
Solid Lipid ◽  
Biodistribution Studies

The main purpose of the present work was studying the biodistribution of amikacin solid lipid nanoparticles (SLNs) after pulmonary delivery to increase its concentration in the lungs for treatment of cystic fibrosis lung infections and also providing a new method for clinical application of amikacin. To achieve this aim,99mTc labelled amikacin was loaded in cholesterol SLNs and afterin vitrooptimization, the desired SLNs and free drug were administered through pulmonary andi.v.routes to male rats and qualitative and biodistribution studies were done. Results showed that pulmonary delivery of SLNs of amikacin by microsprayer caused higher drug concentration in lungs than kidneys whilei.v.administration of free drug caused reverse conditions. It seems that pulmonary delivery of SLNs may improve patients' compliance due to reduction of drug side effects in kidneys and elongation of drug dosing intervals due to the sustained drug release from SLNs.

Trehalose is not a universal solution for solid lipid nanoparticles freeze-drying

2013 ◽  
Vol 19 (8) ◽  
pp. 922-929 ◽  
Author(s):  
Slavomira Doktorovova ◽  
Ranjita Shegokar ◽  
Lisete Fernandes ◽  
Paula Martins-Lopes ◽  
Amélia M. Silva ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Freeze Drying ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Universal Solution
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