A high-pressure chamber is used to study lubricant compressibility when refrigeration oil is diluted by refrigerant. The tested lubricant in this work is a POE (polyol ester) oil, POE diluted with nonchlorinated (HFC) refrigerant R-134a, a naphthenic mineral oil, and the mineral oil diluted with the chlorinated (HCFC) refrigerant R-22. The high-pressure chamber experiments show that by adding 20 wt% of R-134a to the polyol ester oil, the stiffness of the lubricant increases by approximately 38 wt% at 1 GPa and is much higher than for R-22 and mineral oil.