The environmental impact of inhaled therapy: making informed treatment choices

When selecting the best inhaler and drug combination for a patient with respiratory disease, a number of factors should be considered. While efficacy and safety of medical treatments are always a priority, in recent years the environmental impacts of all aspects of life have become an increasingly necessary consideration and inhaled therapies are no exception. The carbon footprint of an item, individual, or organisation, is one of the most important and quantifiable environmental impacts, assessed by the amount of greenhouse gases (often expressed in terms of CO2 equivalents) generated throughout the life cycle. The two most commonly prescribed and manufactured inhaler types worldwide are pressurised metered dose inhalers (pMDIs) containing hydrofluorocarbon (HFC) propellants and dry powder inhalers (DPIs). Most of the carbon footprint of current pMDIs is a result of the propellants that they contain (HFC-134a and HFC-227ea, which are potent greenhouse gases). In comparison, the powder in DPIs is dispersed by the patient's own inhalation, meaning DPIs do not contain a propellant and have a lower carbon footprint than most pMDIs currently available. Soft mist inhalers are another propellant-free option: the device contains a spring, which provides the energy to disperse the aqueous medication. In this review, we will examine the published data on carbon footprint data for inhalers, providing an analysis of potential implications for treatment decision making and industry initiatives.

Thermodynamic Analysis of Eco-Friendly Refrigerant Mixtures as an Alternative to HFC-134a in Household Refrigerator

Nowadays, research has been focused on refrigerants from Hydrofluorocarbons (HFCs), which are not harmful to the ozone layer. Because of replacing refrigerants from chlorofluorocarbons (CFCs) and hydrochlorofluorocarbons (HCFCs). HFCs are used in many applications, including refrigerants, aerosols, solvents, and blowing agents for insulating foams. However, some HFCs have relatively high global warming potential (GWP) and are subject to further examination due to growing concerns about global climate change. The present work’s main objective is to select eco-friendly refrigerants from AC5, R430A and R440A, combining two or more refrigerants from HC, HFC and HFO groups as a direct substitute HFC-134a in a household refrigerator. The performance of the domestic refrigerator with liquid suction heat exchanger (LSHX) was compared in terms of compressor discharge temperature, coefficient of performance (COP), volumetric cooling capacity (VCC), and power consumption of a compressor. It was found that the average COP of R440A and R430A was higher by approximately 2.5% and 1.47% than HFC-134a. However, the COP of AC5 was 6.1% lower than that of HFC-134a. The VCC of R430A is almost equal to HFC-134a. The results also show that AC5, R440A and R430A consume less power than HFC-134a. The compressor outlet temperature with R440A, AC5 provide higher values than HFC-134a, which affects the compressor life. The best overall performance was achieved with the refrigerant R430A in the household refrigerator and suggested an alternative to HFC134a, which also has a very low GWP from the environmental safety perspective.

Energy Analysis of HFC-152a, HFO-1234yf and HFC/HFO Mixtures as a Direct Substitute to HFC-134a in a Domestic Refrigerator

The Kyoto protocol emphasized the need of replacement of HFC refrigerant due to their high GWP values that causes pollution in the environment. So in this paper the refrigerants R1234yf, R152a and HFOs/HFCs mixtures of R134a/R152a/R1234yf such as ARM42 (in the ratio of 8.5/14 /77.5 by mass), ARM42a (in the ratio of 7/11/82 by mass) with a view of replacement of the refrigerant HFC-134a in a domestic refrigerator were analyzed theoretically. Volumetric cooling capacity, compressor discharge temperature, coefficient of performance, compressor energy consumption and refrigeration capacity are the main parameters to estimate the performance of the refrigerator. The results are revealed that HFC-152a had gave a superior performance as compared to HFC-134a in terms of COP and equal cooling and volumetric cooling capacities. However, the refrigerant HFC-152a was flammable and runs with high compressor outlet temperature which may restrict its usage. The HFO refrigerant R1234yf showed an almost equal volumetric cooling capacity, compressor energy consumption, refrigerating effect and COP when compared with HFC-134a. Among the refrigerants ARM42 and ARM42a, the refrigerant ARM42a was selected as a good alternative for HFC-134a because the Volumetric cooling capacity and COP of ARM42a were almost equal to HFC-134a. Therefore ARM42a had better choice of direct substitute to HFC-134a in a domestic refrigerator when the corresponding safety requirements are adopted. So on overall comparison of every property of refrigerants we can conclude that R1234yf can be treated as best alternative to HFC-134a in a domestic refrigerator.

Evidence of a recent decline in UK emissions of hydrofluorocarbons determined by the InTEM inverse model and atmospheric measurements

National greenhouse gas inventories (GHGIs) are submitted annually to the United Nations Framework Convention on Climate Change (UNFCCC). They are estimated in compliance with Intergovernmental Panel on Climate Change (IPCC) methodological guidance using activity data, emission factors and facility-level measurements. For some sources, the outputs from these calculations are very uncertain. Inverse modelling techniques that use high-quality, long-term measurements of atmospheric gases have been developed to provide independent verification of national GHGIs. This is considered good practice by the IPCC as it helps national inventory compilers to verify reported emissions and to reduce emission uncertainty. Emission estimates from the InTEM (Inversion Technique for Emission Modelling) model are presented for the UK for the hydrofluorocarbons (HFCs) reported to the UNFCCC (HFC-125, HFC-134a, HFC-143a, HFC-152a, HFC-23, HFC-32, HFC-227ea, HFC-245fa, HFC-43-10mee and HFC-365mfc). These HFCs have high global warming potentials (GWPs), and the global background mole fractions of all but two are increasing, thus highlighting their relevance to the climate and a need for increasing the accuracy of emission estimation for regulatory purposes. This study presents evidence that the long-term annual increase in growth of HFC-134a has stopped and is now decreasing. For HFC-32 there is an early indication, its rapid global growth period has ended, and there is evidence that the annual increase in global growth for HFC-125 has slowed from 2018. The inverse modelling results indicate that the UK implementation of European Union regulation of HFC emissions has been successful in initiating a decline in UK emissions from 2018. Comparison of the total InTEM UK HFC emissions in 2020 with the average from 2009–2012 shows a drop of 35 %, indicating progress toward the target of a 79 % decrease in sales by 2030. The total InTEM HFC emission estimates (2008–2018) are on average 73 (62–83) % of, or 4.3 (2.7–5.9) Tg CO2-eq yr−1 lower than, the total HFC emission estimates from the UK GHGI. There are also significant discrepancies between the two estimates for the individual HFCs.

The Effect of Catalyst Calcination Temperature on Catalytic Decomposition of HFC-134a over γ-Al2O3

This paper explores the thermal and catalytic pyrolysis of HFC-134a over γ-Al2O3 calcined at temperatures of 550 °C (A550), 650 °C (A650), 750 °C (A750), and 850 °C (A850). The physicochemical properties of catalysts were studied through thermogravimetric analysis (TGA), Brunauer–Emmett–Teller equation for nitrogen physisorption analysis (BET), X-ray diffraction (XRD), and temperature-programmed desorption of ammonia (NH3-TPD). The non-catalytic pyrolysis of HFC-134a showed less than 15% decomposition of HFC-134a. Catalysts increased the decomposition as A650 revealed the highest decomposition efficiency by decomposing more than 95% HFC-134a for 8 h followed by A750, A850, and A550. The larger surface area and pore volume paired with a low amount of strong acidic sites were considered as the main contributors to the comparatively longer catalytic activity of A650.

A Novel Solar Powered Milk Cooling Refrigeration Unit with Cold Thermal Energy Storage for Rural Application

This experimental study analyzed the use of solar photovoltaic energy for operating a novel twin-circuit DC milk chiller without batteries using water-based cold thermal energy storage for different seasons in Chennai, India. HFC-134a and HC-600a were used as refrigerants in the two individual circuits. For each season, the test was conducted continuously for 18 days to analyze the quantity of generated ice that could be utilized to chill 10 L of milk in the morning and in the evening. The average quantity of ice formed per day in the ice bank during monsoon, winter, and summer seasons was found to be 3.61, 19.75, and 27.97 kg, respectively. Thus, it is evident that the use of solar energy with thermal energy storage is effective for operating the milk chilling unit for two seasons, namely winter and summer. However, the system requires an additional power source for continuous operation during the monsoon season. In this study, solar photovoltaic power was observed to be a good choice for chilling milk in the context of global warming and energy consumption. The use of thermal energy storage also allows the initial cost to be reduced.

Swiss halocarbon emissions for 2019 to 2020 assessed from regional atmospheric observations

Halocarbons are emitted by various anthropogenic activities to the atmosphere, where they contribute to global warming and stratospheric ozone-depletion. To determine national halocarbon emissions, the so-called "top-down" approach relies on atmospheric observations, at sites that reflect emissions on a country level, and com-bines these observations with inverse modelling methods. In this study, we present 12 months (September 2019 to September 2020) of continuous atmospheric observations of 28 halocarbons from a measurement campaign at the Beromünster tall tower in Switzerland. The site is sensitive to the most densely populated area of Switzer-land, the Swiss Plateau, thus the measurements were well suited to derive Swiss halocarbon emissions. Emissions were calculated by two different top-down methods, a tracer-ratio method (TRM) with carbon monoxide (CO) as the independent tracer, and a Bayesian inversion (BI), based on atmospheric transport simulations using FLEXPART–COSMO. The results were compared to previously reported top-down emission estimates, based on measurements at the high-Alpine site Jungfraujoch, and to the "bottom-up" Swiss national greenhouse gas (GHG) inventory, as annually reported to the United Nations Framework Convention on Climate Change (UN-FCCC). We observed ongoing outgassing from existing foams and refrigerators for the ozone-depleting, banned chlorofluorocarbons (CFCs) and the regulated hydrochlorofluorocarbons (HCFCs), confirming their large historical use. For the major hydrofluorocarbons (HFCs) HFC-125 (CHF2CF3) and HFC-32 (CH2F2), our calcu-lated emissions of 99 ± 29 Mg yr−1 and 46 ± 13 Mg yr−1 were in good agreement with the national Swiss inventory values, whereas for HFC 134a (CH2FCF3) our result of 300 ± 85 Mg yr−1 was about 30 % lower than the UNFCCC reported value. For the other investigated HFCs, perfluorocarbons (PFCs), SF6 and NF3, emissions were small and in agreement with the inventory. Finally, we report the first country-based emission estimates of a total of 50 Mg yr−1 for three recently phased-in, unregulated hydrofluoroolefins (HFOs), HFO 1234yf (CF3CF=CH2), HFO-1234ze(E) ((E)-CF3CH=CHF) and HCFO-1233zd(E) ((E) CF3CH=CHCl).