Dose-Effect Relationships for the Submandibular Salivary Glands and Implications for Their Sparing by Intensity Modulated Radiotherapy

Abstract Background Xerostomia caused by radiation-induced salivary glands injury has a considerable impact on patients’ quality of life. Nowadays, the existed different methods of evaluating xerostomia in clinical practice there are still some disadvantages and limitations. This study used diffusion-weighted magnetic resonance imaging (DW-MRI) with gustatory stimulation to assess salivary glands function after intensity-modulated radiotherapy (IMRT) in patients with nasopharyngeal carcinoma (NPC). Methods DW-MRI was performed in 30 NPC patients and swab method was used to calculate rest and stimulated salivary flow rates (SFR). DW sequence at rest and then repeated ten times during stimulation were obtained. Apparent diffusion coefficients (ADCs) maps of three glands were calculated. Patients before and after RT were recorded as xerostomia and non-xerostomia groups separately. Rest and stimulated ADCs, ADCs increase rates (IRs), time to maximum ADCs (Tmax), ADCs change rates (CRs), rest and stimulated SFR, SFR increase rates (IRs) and SFR change rates (CRs) before and after RT were assessed. Results The rest and stimulated ADCs of three glands after RT were higher than those before RT (p < 0.001). The rest and stimulated SFR of all salivary glands after RT were lower than those before RT (p < 0.001). A correlation existed between rest ADCs of submandibular glands and rest SFR of submandibular mixed with sublingual glands and full three glands before RT (p = 0.019, p = 0.009), stimulated ADCs and stimulated SFR in parotid glands before RT (p = 0.047). The rest ADCs of parotid glands after RT correlated to XQ scores (p = 0.037). Conclusions The salivary glands’ ADCs increased after RT both in rest and stimulated state due to the radiation injury and the ADCs correlated with SFR and XQ scores of evaluating the xerostomia in clinical practice.

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S034 Intensity-Modulated Radiotherapy (IMRT) Aiming to Reduce Dysphagia: Early Dose-Effect Correlations

Archives of Otolaryngology - Head and Neck Surgery ◽

10.1001/archotol.132.8.845-b ◽

2006 ◽

Vol 132 (8) ◽

pp. 845

Author(s):

A. Eisbruch ◽

T. Lyden ◽

F. Feng ◽

M. Haxer ◽

H. Kim ◽

...

Keyword(s):

Intensity Modulated Radiotherapy ◽

Dose Effect ◽

Intensity Modulated

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Dosimetry evaluation of salivary glands in 3D conformal radiotherapy and intensity modulated radiotherapy in oral tongue cancer

Koomesh journal ◽

10.29252/koomesh.22.1.99 ◽

2020 ◽

Vol 22 (1) ◽

pp. 99-106

Author(s):

Iraj Abedi ◽

Pegah Saadatmand ◽

Hadi Akbari-Zadeh ◽

Alireza Amouheidari ◽

Ahmad Shanei ◽

...

Keyword(s):

Salivary Glands ◽

Tongue Cancer ◽

Intensity Modulated Radiotherapy ◽

Conformal Radiotherapy ◽

Oral Tongue ◽

Intensity Modulated ◽

3D Conformal Radiotherapy ◽

Oral Tongue Cancer

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Dose-effect relationship for 1-year incontinence after post-prostatectomy intensity-modulated radiotherapy (MRT)

European Urology Supplements ◽

10.1016/s1569-9056(19)30697-9 ◽

2019 ◽

Vol 18 (1) ◽

pp. e960-e961

Author(s):

P. Gabriele ◽

D. Cante ◽

G. Sanguineti ◽

F. Munoz ◽

B. Avuzzi ◽

...

Keyword(s):

Intensity Modulated Radiotherapy ◽

Dose Effect ◽

Effect Relationship ◽

Intensity Modulated

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Intensity Modulated Radiotherapy with Carbon Ion Radiotherapy Boost for Acinic Cell Carcinoma of the Salivary Glands

Cancers ◽

10.3390/cancers13010124 ◽

2021 ◽

Vol 13 (1) ◽

pp. 124

Author(s):

Maximilian P. Schmid ◽

Thomas Held ◽

Kristin Lang ◽

Klaus Herfarth ◽

Juliane Hörner-Rieber ◽

...

Keyword(s):

Cell Carcinoma ◽

Salivary Glands ◽

Ion Beam ◽

Intensity Modulated Radiotherapy ◽

Acinic Cell Carcinoma ◽

Carbon Ion Radiotherapy ◽

Definitive Treatment ◽

Carbon Ion ◽

Intensity Modulated ◽

Acinic Cell

Aim: to report clinical outcome in patients with acinic cell carcinoma of the salivary glands treated with intensity-modulated radiotherapy (IMRT) and carbon ion radiotherapy (CIRT) boost. Materials and Methods: all patients with acinic cell carcinoma of the salivary glands treated at the Heidelberg Ion-Beam Therapy Center were considered for this retrospective analysis. All patients received a CIRT boost with 18–24 Gy radiobiologic effectiveness (RBE)-weighted dose in 3 Gy RBE-weighted dose per fraction followed by IMRT, with 50–54 Gy in 2 Gy per fraction. Disease outcome was evaluated for local (LR), nodal (NR), distant recurrence (DR), and disease-free (DFS) and overall survival (OS). Morbidity was scored based on Common Terminology Criteria for Adverse Events (CTCAE) version 5. Descriptive statistics and the Kaplan-Meier method were used for analysis. Results: fifteen patients were available for analysis. Median follow-up after radiotherapy was 43 months. Six patients were treated for primary disease and nine for recurrent disease. Eight patients were treated with radiotherapy for macroscopic disease. Disease recurrence was observed in four patients: 1 LR, 2 NR, and 2 DR; 5-year local control, DFS, and OS were 80%, 52%, and 80%, respectively. No radiotherapy-related G3-5 morbidity was observed. Conclusion: In acinic cell carcinoma, IMRT with carbon ion radiotherapy boost leads to excellent results after R1-resection and is a promising treatment modality for definitive treatment in inoperable patients.

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