Impact of Prophylactic Cranial Irradiation Timing on Brain Relapse Rates in Patients With Stage IIIB Non–Small-Cell Lung Carcinoma Treated With Two Different Chemoradiotherapy Regimens

2012 ◽  
Vol 83 (4) ◽  
pp. 1264-1271 ◽  
Author(s):  
Erkan Topkan ◽  
Cem Parlak ◽  
Ayşe Kotek ◽  
Oznur Yuksel ◽  
Mustafa Cengiz ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Cranial Irradiation ◽  
Prophylactic Cranial Irradiation ◽  
Small Cell ◽  
Stage Iiib ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Relapse Rates

Prospective evaluation of changes in computed cranial tomography in patients with small cell lung carcinoma treated with chemotherapy and prophylactic cranial irradiation.

1984 ◽  
Vol 2 (10) ◽  
pp. 1151-1156 ◽  
Author(s):  
J B Craig ◽  
D V Jackson ◽  
D Moody ◽  
J M Cruz ◽  
E K Pope ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Cerebral Atrophy ◽  
Cranial Irradiation ◽  
Prophylactic Cranial Irradiation ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Multiagent Chemotherapy ◽  
Long Term Survivors

Computed cranial tomographic scans were performed as part of the pretreatment evaluation and at six- to nine-month intervals posttreatment in 13 patients with small cell lung carcinoma. All patients received 3,000 rad of prophylactic cranial irradiation delivered over two weeks in ten treatment fractions in conjunction with multiagent chemotherapy. Posttreatment scans documented an extraordinarily high frequency of abnormalities including cerebral atrophy (100%), ventricular dilatation (70%), and decreased coefficient of absorption in the white matter (15%). Unexplained neurologic abnormalities developed in four of six patients living at least 15 months after institution of therapy. As the number of long-term survivors of this type of lung cancer increases, the need for prospective comprehensive neuropsychologic assessment to determine the clinical significance of these changes is needed.

scholarly journals Utilization of prophylactic cranial irradiation in patients with limited stage small cell lung carcinoma

Cancer ◽  
2010 ◽  
Vol 116 (24) ◽  
pp. 5694-5699 ◽  
Author(s):  
Meredith Giuliani ◽  
Alexander Sun ◽  
Andrea Bezjak ◽  
Clement Ma ◽  
Lisa W. Le ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Cranial Irradiation ◽  
Prophylactic Cranial Irradiation ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Limited Stage
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