single institution
Recently Published Documents


TOTAL DOCUMENTS

10403
(FIVE YEARS 2853)

H-INDEX

108
(FIVE YEARS 11)

2022 ◽  
Vol 43 (2) ◽  
pp. 103296
Author(s):  
Peter K. Moon ◽  
Mahbuba Tusty ◽  
Uchechukwu C. Megwalu

2022 ◽  
Vol 271 ◽  
pp. 82-90
Author(s):  
Luke V. Selby ◽  
Ingrid A. Woelfel ◽  
Mariam Eskander ◽  
Xiaodong Chen ◽  
Michael E. Villarreal ◽  
...  

Cureus ◽  
2022 ◽  
Author(s):  
Clarissa Smith ◽  
Nida Ashraf ◽  
Megan Haghnegahdar ◽  
Kenneth Goins ◽  
Jessica R Newman

Author(s):  
Charles A. Keilin ◽  
Kyle K. VanKoevering ◽  
Jonathan B. McHugh ◽  
Erin L. McKean

Abstract Objectives Sinonasal neuroendocrine carcinomas (SNECs) are among the rarest paranasal sinus cancers. Consensus guidelines for therapy are difficult to develop due to limited data regarding the natural history and successful treatment of these tumors. This study presents 15 years of experience treating SNEC at a single institution and a review of the literature. Design Retrospective review. Setting Academic medical center in the United States. Participants Patients diagnosed with primary SNEC. Main Outcome Measures Overall survival. Results Thirteen patients were identified and included. Overall estimated survival was 74.6% at 5 years. Ten of 13 (76.9%) patients were diagnosed with high-grade neuroendocrine carcinoma and three (23.1%) with intermediate or low grade. All three patients with low- or intermediate-grade cancer survived more than 10 years from their initial diagnosis (median survival: 11.6 years) and are currently alive. The four patients who died had high-grade carcinoma, and estimated overall 5-year survival for all patients with high-grade carcinomas was 65.6%. Five patients, all with high-grade carcinoma, of seven who completed primary chemoradiation therapy (CRT) required salvage resection, and 60% are alive without disease. Conclusion This cohort has a higher overall rate of survival than many recent case series and reviews. There is consensus that multimodal therapy is preferred over monotherapy, but approaches to treatment vary widely. Our approach of surgical resection as primary therapy for low-grade tumors and primary CRT for high-grade SNEC has been successful, and could indicate hope for improved survival among these patients.


Sign in / Sign up

Export Citation Format

Share Document