The Influence of Postoperative Lymph Node Radiation Therapy on Overall Survival of Patients With Stage III Melanoma: A National Cancer Data Base Analysis

2016 ◽  
Vol 96 (2) ◽  
pp. S157-S158
Author(s):  
H. Danish ◽  
K. Patel ◽  
J. Switchenko ◽  
T.W. Gillespie ◽  
J. Jhaveri ◽  
...  
Cancer ◽  
2017 ◽  
Vol 123 (17) ◽  
pp. 3402-3409 ◽  
Author(s):  
Priscilla K. Stumpf ◽  
Arya Amini ◽  
Bernard L. Jones ◽  
Matthew Koshy ◽  
David J. Sher ◽  
...  

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e19000-e19000
Author(s):  
Arden Fredeking ◽  
Suraj S. Venna ◽  
Sekwon Jang

e19000 Background: The 5-year survival of Stage III melanoma ranges from 30-70%. High dose interferon alfa-2b (IFN) is an adjuvant immunotherapy approved in 1995 for stage III melanoma, however, its use has been limited by its significant toxicity and modest benefit. We hypothesized the utilization of adjuvant immunotherapy is less in older age group compared to younger patients. Methods: Using the National Cancer Data Base (NCDB) aggregate data, demographic, socioeconomic, insurance information, and treatment data were analyzed. Proportions were compared using Pearson Chi squared tests. Results: From 2000-2008, 27,365 cases of stage III melanoma were reported to NCDB. Most patients were male (63%) and Caucasian (94.2%). Twenty-nine percent were over the age of 70. Educational and socioeconomic factors across all age groups were not significantly different. The primary insurer for patients younger than 60 was a managed care plan (54.3%) as compared to Medicare with supplemental insurance for patients older than 60 (47.4%). In terms of systemic therapy, 23% received immunotherapy alone, 6% received chemotherapy alone, 2% received both, and 66% received no therapy. When compared to patients under age 39, older age groups were significantly less likely to receive adjuvant immunotherapy as shown in the table below. Conclusions: There is an inverse relationship between age and the use of adjuvant immunotherapy. Further study is planned to adjust for comorbidity, socioeconomic status using patient-level data. [Table: see text]


2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 4519-4519 ◽  
Author(s):  
Claudio Jeldres ◽  
Khanh Ngoc Pham ◽  
Siamak Daneshmand ◽  
Christian K. Kollmannsberger ◽  
Brandon M. Hayes-Lattin ◽  
...  

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