scholarly journals Efficacy and Toxicity Profile of Brain Metastasis Treatment with Mask-based, Fractionated Stereotactic Radiosurgery

2020 ◽  
Vol 108 (3) ◽  
pp. e677
Author(s):  
K.A. Ward ◽  
D. Seneviratne ◽  
S.W. Dutta ◽  
M.L. Mack ◽  
D. Schlesinger ◽  
...  
Keyword(s):  
Brain Metastasis ◽  
Stereotactic Radiosurgery ◽  
Toxicity Profile ◽  
Fractionated Stereotactic Radiosurgery

Multi-institutional validation of brain metastasis velocity, a recently defined predictor of outcomes following stereotactic radiosurgery

2020 ◽  
Vol 142 ◽  
pp. 168-174 ◽  
Author(s):  
Emory R. McTyre ◽  
Michael H. Soike ◽  
Michael Farris ◽  
Diandra N. Ayala-Peacock ◽  
Jaroslaw T. Hepel ◽  
...  
Keyword(s):  
Brain Metastasis ◽  
Stereotactic Radiosurgery

Hospitalization outcomes of radiation therapy ± stereotactic radiosurgery for brain metastasis

2021 ◽  
Vol 61 ◽  
pp. 13
Author(s):  
HA Beydoun ◽  
MA Beydoun ◽  
S Huang ◽  
SM Eid ◽  
AB Zonderman
Keyword(s):  
Radiation Therapy ◽  
Brain Metastasis ◽  
Stereotactic Radiosurgery

Timing of Adjuvant Fractionated Stereotactic Radiosurgery Impacts Local Control of Resected Brain Metastases

2021 ◽  
Author(s):  
Diana A. Roth O‘Brien ◽  
Phillip Poppas ◽  
Sydney M. Kaye ◽  
Sean S. Mahase ◽  
Anjile An ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Stereotactic Radiosurgery ◽  
Local Control ◽  
Fractionated Stereotactic Radiosurgery

scholarly journals Fractionated stereotactic radiosurgery for patients with skull base metastases from systemic cancer involving the anterior visual pathway

2014 ◽  
Vol 9 (1) ◽  
Author(s):  
Giuseppe Minniti ◽  
Vincenzo Esposito ◽  
Enrico Clarke ◽  
Claudia Scaringi ◽  
Alessandro Bozzao ◽  
...  
Keyword(s):  
Skull Base ◽  
Stereotactic Radiosurgery ◽  
Visual Pathway ◽  
Fractionated Stereotactic Radiosurgery ◽  
Skull Base Metastases

RADT-03. OUTCOMES OF PATIENTS WITH HER2-POSITIVE BREAST CANCER METASTATIC TO BRAIN TREATED WITH HER2-TARGETED SYSTEMIC THERAPY AND STEREOTACTIC RADIOSURGERY

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi41-vi41
Author(s):  
John Shumway ◽  
Marina Torras ◽  
Katherine Reeder-Hayes ◽  
Trevor Jolly ◽  
Elizabeth Dees ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Brain Metastasis ◽  
Stereotactic Radiosurgery ◽  
Systemic Therapy ◽  
Survival Outcomes ◽  
Maximal Dimension ◽  
Her2 Positive ◽  
Intracranial Metastasis ◽  
Her2 Positive Breast Cancer ◽  
Positive Breast Cancer

Abstract OBJECTIVE For patients with HER2-positive breast cancer metastatic to brain, HER2-directed systemic therapies are increasingly used with stereotactic radiosurgery (SRS). These include monoclonal antibodies such as trastuzumab (H) and pertuzumab (P), antibody-drug conjugates such as ado-trastuzumab emtansine (T-DM1), and tyrosine kinase inhibitors such as lapatinib. Limited data exist regarding appropriate timing with SRS and outcomes of this treatment regimen. METHODS A single-institution retrospective review collected clinical data on patients with breast cancer metastatic to brain who were treated with SRS from 2009-2020. Statistical analyses were performed using the Kaplan-Meier method and chi-square statistic. RESULTS Of 82 patients with breast cancer metastatic to brain treated with SRS, 33 (40%) were HER2-positive, 18 of whom were hormone receptor-positive. At brain metastasis diagnosis, 15 patients (45%) had >1 intracranial metastasis (range 2-7), and the median brain metastasis maximal dimension was 2.0 cm. Fifteen patients had uncontrolled extracranial disease. After brain metastasis diagnosis, 9 patients (27%) were treated with systemic therapy first (T-DM1+/-HP, lapatinib+HP, chemotherapy+/-HP) followed by SRS at a median of 18.6 months after starting systemic therapy. Seven patients (21%) were treated with SRS first, followed by systemic therapy in 6 of these patients (multi-agent regimens, 4 including T-DM1 or lapatinib). Seventeen (52%) received concurrent systemic therapy and SRS (T-DM1+/-chemotherapy, lapatinib, HP, hormone therapy, chemotherapy). Median follow-up time was 21.1 months. Median overall survival was 24.8 months and not statistically different between treatment groups. Four patients (12%) developed symptomatic radionecrosis; 3 were on T-DM1 concurrent with SRS. CONCLUSION In this small patient sample, we noted favorable survival outcomes for patients with HER2-positive breast cancer metastatic to brain when treated with HER2-targeted therapies together with SRS. The sequence of systemic therapy and SRS does not appear to impact survival outcomes. Concurrent treatment with T-DM1 and SRS may be associated with higher rates of radionecrosis.

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