Institutional Outcomes of Whole Brain Radiotherapy for Metastatic Melanoma Brain Metastases

2020 ◽  
Vol 108 (3) ◽  
pp. e687
Author(s):  
C. Jiang ◽  
J. Switchenko ◽  
D. Lawson ◽  
M. Yushak ◽  
M.K. Khan
Keyword(s):  
Brain Metastases ◽  
Metastatic Melanoma ◽  
Whole Brain Radiotherapy ◽  
Whole Brain ◽  
Brain Radiotherapy ◽  
Melanoma Brain Metastases

scholarly journals Accrual to a randomised trial of adjuvant whole brain radiotherapy for treatment of melanoma brain metastases is feasible

2014 ◽  
Vol 7 (1) ◽  
Author(s):  
Gerald B Fogarty ◽  
Angela Hong ◽  
Kari Dolven Jacobsen ◽  
Claudius H Reisse ◽  
Brindha Shivalingam ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Randomised Trial ◽  
Whole Brain Radiotherapy ◽  
Whole Brain ◽  
Brain Radiotherapy ◽  
Melanoma Brain Metastases

scholarly journals Whole Brain Radiotherapy and RRx-001: Two Partial Responses in Radioresistant Melanoma Brain Metastases from a Phase I/II Clinical Trial

2016 ◽  
Vol 9 (2) ◽  
pp. 108-113 ◽  
Author(s):  
Michelle M. Kim ◽  
Hemant Parmar ◽  
Yue Cao ◽  
Priyanka Pramanik ◽  
Matthew Schipper ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Brain Metastases ◽  
Phase I ◽  
Whole Brain Radiotherapy ◽  
Whole Brain ◽  
Brain Radiotherapy ◽  
Melanoma Brain Metastases

scholarly journals Concurrent whole brain radiotherapy and RRx-001 for melanoma brain metastases

2016 ◽  
Vol 18 (3) ◽  
pp. 455-456 ◽  
Author(s):  
Michelle M. Kim ◽  
Hemant Parmar ◽  
Yue Cao ◽  
Susan J. Knox ◽  
Bryan Oronsky ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Whole Brain Radiotherapy ◽  
Whole Brain ◽  
Brain Radiotherapy ◽  
Melanoma Brain Metastases

Radiosurgery without whole brain radiotherapy in melanoma brain metastases

1998 ◽  
Vol 34 (8) ◽  
pp. 1187-1192 ◽  
Author(s):  
J.J. Grob ◽  
J. Regis ◽  
R. Laurans ◽  
M. Delaunay ◽  
P. Wolkenstein ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Whole Brain Radiotherapy ◽  
Whole Brain ◽  
Brain Radiotherapy ◽  
Melanoma Brain Metastases

scholarly journals Management of Melanoma Brain Metastases in the Era of Targeted Therapy

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Daniela Gonsalves Shapiro ◽  
Wolfram E. Samlowski
Keyword(s):  
Targeted Therapy ◽  
Brain Metastases ◽  
Metastatic Disease ◽  
Treatment Options ◽  
Whole Brain Radiotherapy ◽  
Whole Brain ◽  
Brain Radiotherapy ◽  
Novel Treatment ◽  
Melanoma Brain Metastases ◽  
Melanoma Patients

Disseminated metastatic disease, including brain metastases, is commonly encountered in malignant melanoma. The classical treatment approach for melanoma brain metastases has been neurosurgical resection followed by whole brain radiotherapy. Traditionally, if lesions were either too numerous or surgical intervention would cause substantial neurologic deficits, patients were either treated with whole brain radiotherapy or referred to hospice and supportive care. Chemotherapy has not proven effective in treating brain metastases. Improvements in surgery, radiosurgery, and new drug discoveries have provided a wider range of treatment options. Additionally, recently discovered mutations in the melanoma genome have led to the development of “targeted therapy.” These vastly improved options are resulting in novel treatment paradigms for approaching melanoma brain metastases in patients with and without systemic metastatic disease. It is therefore likely that improved survival can currently be achieved in at least a subset of melanoma patients with brain metastases.

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