Modern possibilities of immunotherapy in the treatment of extensive-stage small cell lung cancer: experience of durvalumab application. Case report

Extensive-stage small cell lung cancer (ES-SCLC) is characterized by an aggressive course, a high recurrence rate and fast progression. For a long time, the survival prognosis for the most patients suffering from this disease remained unfavorable. The situation changed with the appearance of chemoimmunotherapy in clinical practice. Chemotherapy based on durvalumab in comparison with the standard chemotherapy demonstrated the statistically and clinically significant increase in median overall survival in patients with previously untreated ES-SCLC in the CASPIAN international trial. This article deals with the case of the application of standard chemotherapy in combination with durvalumab as a first-line ES-SCLC therapy. The patient started receiving durvalumab therapy in June 2017 as a part of the CASPIAN international trial. In March 2021 the duration of therapy was 45 months, the patient had a complete regression of the disease.

Legal Assessment and Speculation on the Topic of Collaborationism in Ukraine. Digital Dimension

The majority of modern researchers of the history of WWII and Great Patriotic War (1939-1945), analyzing the events that took place seventy years ago speak about the extreme danger of Nazism, since its aggression, in the case of the Nazis’ victory, would cause a civilizational decline for considerable part of mankind, and would lead to humanitarian catastrophe. A significant number of innocent people got into the post-war repression and their fates were crippled by war and totalitarianism. The author of this paper does not in any way desire to justify activities of collaborators or enemy aiders and deserters, as certain historian critics sometimes mistakenly imagine. Our research aims to show – but not to justify – motives of deeds of a person in critical social settings and incentive factors, which may under certain conditions align one’s behavior with a specific course of action. We believe that any statements concerning the inadmissibility of the Nuremberg International Trial rulings review are incompetent and illegitimate.

‘MUCH TO DELIVER IN YOUR HONOUR'S EAR’: ANGELO NOTARI’S WORK IN INTELLIGENCE, 1616–1623

It has long been surmised that the Paduan singer, lutenist and composer Angelo Notari (1566–1663) was employed as a spy after immigrating to England circa 1610. In examining Venetian counterintelligence papers previously neglected by musicologists, I here confirm that Notari was indeed an intelligencer. More specifically, he was a paid informant for the Venetian State Inquisitors between 1616 and 1619 and participated in a contentious international trial concerning the Venetian ambassador to England, Antonio Foscarini. I argue that Notari's work as a musician was inextricable from his identity as an intelligencer and former Venetian citizen and demonstrate that Italian musicians in Jacobean London significantly influenced international diplomatic relations. By identifying intersections between the two highly social practices of music-making and intelligence-gathering, I encourage greater musicological attention to political networks that transmitted music across borders and, conversely, musical networks that transmitted political intelligence. I thus situate seventeenth-century musical transculturation within its broader diplomatic, confessional and economic contexts.