Pharmacological inhibition of HSP90 radiosensitizes HNSCC xenograft by inhibition of DNA damage repair, nucleotide metabolism, and radiation-induced tumor vasculogenesis

2021 ◽  
Author(s):  
Sarwat Naz ◽  
Andrew J. Leiker ◽  
Rajani Choudhuri ◽  
Olivia Preston ◽  
Anastasia L. Sowers ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Damage Repair ◽  
Nucleotide Metabolism ◽  
Pharmacological Inhibition ◽  
Damage Repair ◽  
Radiation Induced

scholarly journals PDTB-10. INHIBITION OF RADIATION-INDUCED DNA DAMAGE REPAIR MEDIATED CHROMATIN MODIFICATION BY HISTONE H3 DEMETHYLASE INHIBITOR IN PEDIATRIC BRAINSTEM GLIOMA

2016 ◽  
Vol 18 (suppl_6) ◽  
pp. vi151-vi152
Author(s):  
Quanhong Ma ◽  
Andrea Plunti ◽  
Amanda Saratsis ◽  
Rishi Lulla ◽  
Jason R Fangusaro ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Damage Repair ◽  
Chromatin Modification ◽  
Histone H3 ◽  
Brainstem Glioma ◽  
Damage Repair ◽  
Radiation Induced

Radiation Induced DNA-Damage/Repair and Associated Signaling Pathways

2008 ◽  
pp. 249-266 ◽  
Author(s):  
Bo Stenerlöw ◽  
Lina Ekerljung ◽  
Jörgen Carlsson ◽  
Johan Lennartsson
Keyword(s):  
Dna Damage ◽  
Signaling Pathways ◽  
Dna Damage Repair ◽  
Damage Repair ◽  
Radiation Induced

Analysis of ionizing radiation-induced foci of DNA damage repair proteins

2005 ◽  
Vol 574 (1-2) ◽  
pp. 22-33 ◽  
Author(s):  
Lieneke R. van Veelen ◽  
Tiziana Cervelli ◽  
Mandy W.M.M. van de Rakt ◽  
Arjan F. Theil ◽  
Jeroen Essers ◽  
...  
Keyword(s):  
Dna Damage ◽  
Ionizing Radiation ◽  
Dna Damage Repair ◽  
Damage Repair ◽  
Radiation Induced

scholarly journals Tumor Cell–Accelerated Senescence Is Associated With DNA-PKcs Status and Telomere Dysfunction Induced by Radiation

Dose-Response ◽  
2018 ◽  
Vol 16 (2) ◽  
pp. 155932581877152 ◽  
Author(s):  
Miaomiao Zhang ◽  
Xiaopeng Guo ◽  
Yue Gao ◽  
Dong Lu ◽  
Wenjian Li
Keyword(s):  
Dna Damage ◽  
Real Time ◽  
Genome Instability ◽  
Dna Damage Repair ◽  
Cancer Cell Line ◽  
Histochemical Staining ◽  
Damage Repair ◽  
Radiation Induced ◽  
Accelerated Senescence ◽  
Mcf 7

Whether telomere structure integrity is related to radiosensitivity is not well investigated thus far. In this study, we investigated the relation between telomere instability and radiation-induced accelerated senescence. Partial knockdown of DNA-dependent catalytic subunit of protein kinase (DNA-PKcs) in human breast cancer cell line MCF-7 was established by small interfering RNA. Radiosensitivity of control and DNA-PKcs knockdown MCF-7 cells was analyzed by clonogenetic assay. Cell growth was measured by real-time cell electronic sensing. Senescence and apoptosis were evaluated by β-galactosidase histochemical staining and fluorescence-activated cell sorting, respectively. DNA damage was determined by long polymerase chain reaction (PCR). Telomere length and integrity were analyzed by real-time PCR and cytogenetic assay, respectively. DNA-PKcs knockdown MCF-7 cells were more sensitive to X-irradiation than control cells. Further investigation revealed that accelerated senescence is more pronounced than apoptosis in cells after radiation, particularly in DNA-PKcs knockdown cells. The cytogenetic assay and kinetics of DNA damage repair revealed that the role of telomere end-capping in DNA-PKcs, rather than DNA damage repair, was more relevant to radiosensitivity. To our knowledge, this is the first study to show that DNA-PKcs plays an important role in radiation-induced accelerated senescence via maintenance of telomere integrity in MCF-7 cells. These results could be useful for future understanding of the radiation-induced genome instability and its consequences.

scholarly journals Glutamine Synthetase Promotes Radiation Resistance via Facilitating Nucleotide Metabolism and Subsequent DNA Damage Repair

Cell Reports ◽  
2019 ◽  
Vol 28 (5) ◽  
pp. 1136-1143.e4 ◽  
Author(s):  
Shujun Fu ◽  
Zhi Li ◽  
Lanbo Xiao ◽  
Wenfeng Hu ◽  
Lu Zhang ◽  
...  
Keyword(s):  
Dna Damage ◽  
Glutamine Synthetase ◽  
Radiation Resistance ◽  
Dna Damage Repair ◽  
Nucleotide Metabolism ◽  
Damage Repair

Radiation-Induced Survivin Nuclear Accumulation is Linked to DNA Damage Repair

2010 ◽  
Vol 77 (1) ◽  
pp. 226-234 ◽  
Author(s):  
Gianni Capalbo ◽  
Klaus Dittmann ◽  
Christian Weiss ◽  
Sebastian Reichert ◽  
Eva Hausmann ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Damage Repair ◽  
Nuclear Accumulation ◽  
Damage Repair ◽  
Radiation Induced

Radiation-Induced Upregulation of Gene Expression From Adenoviral Vectors Mediated by DNA Damage Repair and Regulation

2012 ◽  
Vol 83 (1) ◽  
pp. 376-384 ◽  
Author(s):  
Petri Nokisalmi ◽  
Maria Rajecki ◽  
Sari Pesonen ◽  
Sophie Escutenaire ◽  
Rabah Soliymani ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Damage ◽  
Dna Damage Repair ◽  
Adenoviral Vectors ◽  
Damage Repair ◽  
Radiation Induced
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