A commentary on “Endoscopic versus percutaneous biliary drainage for resectable pancreatic head cancer with hyperbilirubinemia and impact on pancreaticoduodenectomy: A randomized controlled study.” (Int J Surg 2021, Sept 1; 93:106043)

2021 ◽  
pp. 106144
Author(s):  
Aleksandar Radulović ◽  
Sharmananthan Ganesananthan ◽  
Zoe Oakley
Keyword(s):  
Biliary Drainage ◽  
Pancreatic Head ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Head Cancer ◽  
Pancreatic Head Cancer ◽  
Percutaneous Biliary Drainage ◽  
Randomized Controlled

Efficacy of endoscopic samplings during initial biliary drainage for cases of pancreatic head cancer: United diagnostic yields of multiple pathological samplings

Pancreatology ◽  
2021 ◽  
Author(s):  
Hiroyuki Matsubayashi ◽  
Keiko Sasaki ◽  
Sachiyo Ono ◽  
Hirotoshi Ishiwatari ◽  
Kazuma Ishikawa ◽  
...  
Keyword(s):  
Biliary Drainage ◽  
Pancreatic Head ◽  
Head Cancer ◽  
Pancreatic Head Cancer

scholarly journals Preoperative Biliary Drainage of Jaundiced Patients with Pancreatic Head Cancer: A Routine or Selective Strategy

2017 ◽  
Vol 07 (02) ◽  
Author(s):  
Tshijanu F ◽  
Toutouzas K ◽  
Mubaminyi L ◽  
Pidireki A ◽  
Alexakis N ◽  
...  
Keyword(s):  
Biliary Drainage ◽  
Pancreatic Head ◽  
Preoperative Biliary Drainage ◽  
Head Cancer ◽  
Pancreatic Head Cancer ◽  
Selective Strategy

Extended Versus Standard Lymphadenectomy for Pancreatic Head Cancer: Meta-Analysis of Randomized Controlled Trials

2015 ◽  
Vol 19 (9) ◽  
pp. 1725-1732 ◽  
Author(s):  
Bobby V M Dasari ◽  
Sandro Pasquali ◽  
Ravinder S Vohra ◽  
Andrew M Smith ◽  
Mark A Taylor ◽  
...  
Keyword(s):  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Pancreatic Head ◽  
Controlled Trials ◽  
Head Cancer ◽  
Pancreatic Head Cancer ◽  
Randomized Controlled

scholarly journals 435 Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials Comparing Standard Versus Extended Lymphadenectomy Pancreatoduodenectomy For Adenocarcinoma of The Head of Pancreas

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
A Kotb ◽  
S Hajibandeh ◽  
S Hajibandeh ◽  
T Satyadas
Keyword(s):  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Pancreatic Head ◽  
Trial Sequential Analysis ◽  
Survival Outcomes ◽  
Controlled Trials ◽  
Extended Lymphadenectomy ◽  
Head Cancer ◽  
Pancreatic Head Cancer ◽  
Randomized Controlled

Abstract Aim To compare baseline demographics, operative, and survival outcomes of randomized controlled trials (RCTs) comparing standard versus extended lymphadenectomy in patients undergoing pancreaticoduodenectomy for pancreatic head cancer Method we performed a meta-analysis of baseline demographics, operative, and survival outcomes of RCTs comparing standard versus extended lymphadenectomy in patients undergoing pancreaticoduodenectomy for pancreatic head cancer. The uncertainties associated with varying follow-up periods among the included studies were resolved by analysis of time-to-event outcomes. Moreover, we performed trial sequential analysis (TSA) to determine whether the available evidence is conclusive and to assess the risk of type 1 or type 2 errors. Results Overall, 724 patients from 5 RCTs were included. There was no difference between standard and extended lymphadenectomy in terms of pancreatic fistula (OR0.64, P = 0.11), delayed gastric emptying (OR 0.68, P = 0.40), bile leak (OR 0.33, P = 0.06), wound infection (OR 0.53, P = 0.06), abscess (OR 0.83, P = 0.63), total complications (OR 0.73, P = 0.27), postoperative mortality (OR 1.01, P = 0.85), and overall survival (HR 1.10, P = 0.46). TSA suggested that meta-analysis was conclusive with low risk of type 2 error. Conclusions Robust evidence from randomized controlled trials (Level 1) suggests no difference in postoperative and survival outcomes between standard and extended lymphadenectomy in patients undergoing pancreaticoduodenectomy for pancreatic head cancer. The findings were consistent in patients with positive and negative lymph node status and in studies from the West or East.

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