As the focal length of an optical lens in a conventional camera is limited, it is usually arduous to obtain an image in which each object is focused. This problem can be solved by multi-focus image fusion. In this paper, we propose an entirely new multi-focus image fusion method based on decision map and sparse representation (DMSR). First, we obtained a decision map by analyzing low-scale images with sparse representation, measuring the effective clarity level, and using spatial frequency methods to process uncertain areas. Subsequently, the transitional area around the focus boundary was determined by the decision map, and we implemented the transitional area fusion based on sparse representation. The experimental results show that the proposed method is superior to the other five fusion methods, both in terms of visual effect and quantitative evaluation.